Based on the study "The association of virulence factors with genomic islands" (Ho Sui, Fedynak, Hsiao, Langille, and Brinkman (2009), PLoS ONE).
Updated August 1, 2013
BLAST similarity searches were performed against the deduced proteomes of 750 pathogenic and 913 non-pathogenic sequenced prokaryotic genomes downloaded from the National Center for Biotechnology Information FTP site in January 2013. An e-value cut-off of 10-7 was used to exclude some homologs. Pathogen or non-pathogen status for each genome was obtained through the NCBI Complete Microbial Genomes webpage (Haft et al. 2005) and then manually curated to ensure data quality and completeness.
Important notes on this analysis:
- We would like to emphasize that this is a very simple analysis to be used as a guide only.
- The list of genes defined as being pathogen-associated will continue to change as more genomes are sequenced. The analysis will be updated on a regular basis in order to reflect this.