Use this list to search for genes that have been manually assigned GO terms by PseudoCAP curators. In most cases, the terms were assigned to P. aeruginosa PAO1 and transferred to conservative orthologs in other P. aeruginosa strains.
Criteria for assigning a GO term to orthologs consists of belonging to the same Pseudomonas Ortholog Group (POG), not having multiple top blast hits in the RBBH phase of the analysis (to help rule out paralogs) and finally not being classified as an ortholog fragment (i.e. gene length is less than 1/4 of the median length of the ortholog group).
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1This list only contains GO terms that have been reviewed and manually assigned to at least one gene.
Only show annotations reviewed by a curator?
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* Please note: We discourage searches of the original Pseudomonas aeruginosa PAO1 (Sept 2000) annotation since it is not updated
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Virulence factor gene list based on manual curation from the Pseudomonas Genome Database and data from the Virulence Factor Database as described by Yang et al.(2008)

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Based on the study "The association of virulence factors with genomic islands" (Ho Sui, Fedynak, Hsiao, Langille, and Brinkman (2009), PLoS ONE).

Updated August 1, 2013
BLAST similarity searches were performed against the deduced proteomes of 750 pathogenic and 913 non-pathogenic sequenced prokaryotic genomes downloaded from the National Center for Biotechnology Information FTP site in January 2013. An e-value cut-off of 10-7 was used to exclude some homologs. Pathogen or non-pathogen status for each genome was obtained through the NCBI Complete Microbial Genomes webpage (Haft et al. 2005) and then manually curated to ensure data quality and completeness.

Important notes on this analysis:

  1. We would like to emphasize that this is a very simple analysis to be used as a guide only.
  2. The list of genes defined as being pathogen-associated will continue to change as more genomes are sequenced. The analysis will be updated on a regular basis in order to reflect this.
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Currently we only have drug target information for Pseudomonas aeruginosa PAO1.

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