Pseudomonas aeruginosa PAO1, PA0225 (erfA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0225
Name
erfA
Replicon chromosome
Genomic location 254791 - 255330 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_248916.1
GI 15595422
Affymetrix PA0225_at
Entrez 880191
GenBank AAG03614.1
INSDC AAG03614.1
NCBI Locus Tag PA0225
protein_id(GenBank) gb|AAG03614.1|AE004460_7|gnl|PseudoCAP|PA0225
TIGR NTL03PA00226
UniParc UPI00000C4FA8
UniProtKB Acc Q9I6R3
UniProtKB ID Q9I6R3_PSEAE
UniRef100 UniRef100_U8MFK4
UniRef50 UniRef50_A6UY22
UniRef90 UniRef90_A6UY22

Product

Feature Type CDS
Coding Frame 1
Product Name
ErfA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.32
Kyte-Doolittle Hydrophobicity Value -0.293
Molecular Weight (kDa) 20.0
Isoelectric Point (pI) 6.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 373 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000224 (424 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0225
Search term: erfA
Search term: ErfA

Human Homologs

References

Species-specific recruitment of transcription factors dictates toxin expression.
Trouillon J, Sentausa E, Ragno M, Robert-Genthon M, Lory S, Attrée I, Elsen S
Nucleic Acids Res 2020 Mar 18;48(5):2388-2400
PubMed ID: 31925438