Pseudomonas aeruginosa PAO1, PA0425 (mexA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0042910 xenobiotic transmembrane transporter activity
IMP
Inferred from Mutant Phenotype 		ECO:0000015
mutant phenotype evidence		 8540696 Reviewed by curator
Biological Process GO:0046677 response to antibiotic
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 8540696 Reviewed by curator
Molecular Function GO:0042910 xenobiotic transmembrane transporter activity
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 8540696 Reviewed by curator
Molecular Function GO:0022857 transmembrane transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0055085 transmembrane transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00529
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Antibiotic resistance and susceptibility Other PAO1 genes in this class
Transport of small molecules Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01501 beta-Lactam resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:2.40.30.170 - - - 56 268 2.9E-64
PANTHER PTHR30158 ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER - - 10 373 2.7E-124
Pfam PF00529 Cation efflux system protein CusB domain 1 IPR043602 Cation efflux system protein CusB, domain 1 279 346 1.3E-8
FunFam G3DSA:2.40.30.170:FF:000001 Multidrug resistance efflux transporter MdtE - - 188 269 8.2E-38
SUPERFAMILY SSF111369 HlyD-like secretion proteins - - 49 285 3.79E-94
NCBIfam TIGR01730 JCVI: efflux RND transporter periplasmic adaptor subunit IPR006143 RND efflux pump, membrane fusion protein 38 360 1.6E-76
Coils Coil Coil - - 103 123 -
Gene3D G3DSA:2.40.50.100 - - - 62 192 2.9E-64
Pfam PF16576 Barrel-sandwich domain of CusB or HlyD membrane-fusion IPR032317 RND efflux pump, membrane fusion protein, barrel-sandwich domain 59 278 6.7E-16
FunFam G3DSA:2.40.420.20:FF:000001 Efflux RND transporter periplasmic adaptor subunit - - 269 361 2.0E-31
Gene3D G3DSA:1.10.287.470 Helix hairpin bin - - 97 156 2.9E-64
Gene3D G3DSA:2.40.420.20 - - - 269 362 5.3E-23

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.