Pseudomonas aeruginosa PAO1, PA1120 (tpbB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0052621 diguanylate cyclase activity
IDA
Inferred from Direct Assay
ECO:0000005
enzyme assay evidence
16477007 Reviewed by curator
Molecular Function GO:0052621 diguanylate cyclase activity
ISS
Inferred from Sequence or Structural Similarity
Term mapped from: PseudoCAP:PA14_49890
ECO:0000250
sequence similarity evidence used in manual assertion
19543378 Reviewed by curator
Molecular Function GO:0052621 diguanylate cyclase activity
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
19543378 Reviewed by curator
Biological Process GO:0007165 signal transduction
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00304
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SM00304
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Motility & Attachment Other PAO1 genes in this class
Membrane proteins Other PAO1 genes in this class
Nucleotide biosynthesis and metabolism Other PAO1 genes in this class
Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02025 Biofilm formation - Pseudomonas aeruginosa 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SMART SM00267 duf1_3 IPR000160 GGDEF domain 238 411 2.0E-56
Pfam PF17152 Periplasmic sensor domain IPR033417 Periplasmic sensor domain CHASE8 45 145 7.4E-33
Gene3D G3DSA:6.10.340.10 - - - 145 241 8.7E-8
CDD cd01949 GGDEF IPR000160 GGDEF domain 250 406 5.70956E-60
Pfam PF00990 Diguanylate cyclase, GGDEF domain IPR000160 GGDEF domain 249 405 1.4E-46
Pfam PF00672 HAMP domain IPR003660 HAMP domain 181 232 5.5E-9
MobiDBLite mobidb-lite consensus disorder prediction - - 413 435 -
SUPERFAMILY SSF55073 Nucleotide cyclase IPR029787 Nucleotide cyclase 254 408 1.02E-44
MobiDBLite mobidb-lite consensus disorder prediction - - 413 429 -
PANTHER PTHR46663 DIGUANYLATE CYCLASE DGCT-RELATED - - 117 427 1.1E-74
Coils Coil Coil - - 217 244 -
Gene3D G3DSA:3.30.70.270 - IPR043128 Reverse transcriptase/Diguanylate cyclase domain 254 413 4.6E-55
FunFam G3DSA:3.30.70.270:FF:000090 Diguanylate cyclase TpbB - - 254 413 2.5E-106
SMART SM00304 HAMP_11 IPR003660 HAMP domain 183 236 9.6E-8
NCBIfam TIGR00254 JCVI: diguanylate cyclase (GGDEF) domain IPR000160 GGDEF domain 245 408 3.7E-44
CDD cd06225 HAMP - - 186 231 4.22773E-5

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.