Pseudomonas aeruginosa PAO1, PA1562 (acnA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P25516
|
ECO:0000250 sequence similarity evidence used in manual assertion |
7588761 | Reviewed by curator |
| Cellular Component | GO:0005737 | cytoplasm |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P25516
|
ECO:0000250 sequence similarity evidence used in manual assertion |
12486059 | Reviewed by curator |
| Molecular Function | GO:0005506 | iron ion binding |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P25516
|
ECO:0000250 sequence similarity evidence used in manual assertion |
12486059 | Reviewed by curator |
| Biological Process | GO:0009061 | anaerobic respiration |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P25516
|
ECO:0000250 sequence similarity evidence used in manual assertion |
12486059 | Reviewed by curator |
| Molecular Function | GO:0003994 | aconitate hydratase activity |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P25516
|
ECO:0000250 sequence similarity evidence used in manual assertion |
7588761 | Reviewed by curator |
| Biological Process | GO:0006979 | response to oxidative stress |
Inferred from Sequence or Structural Similarity
Term mapped from: UniProtKB:P25516
|
ECO:0000250 sequence similarity evidence used in manual assertion |
12486059 | Reviewed by curator |
Functional Classifications Manually Assigned by PseudoCAP
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| PseudoCyc | ANARESP1-PWY | anaerobic respiration | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae01120 | Microbial metabolism in diverse environments | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae01100 | Metabolic pathways | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | GLYOXYLATE-BYPASS | glyoxylate cycle | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | P106-PWY | serine-isocitrate lyase pathway | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | P22-PWY | acetyl-CoA assimilation | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| KEGG | pae01200 | Carbon metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCAP | Glyoxylate and dicarboxylate metabolism |
ECO:0000037
not_recorded |
|||
| KEGG | pae00020 | Citrate cycle (TCA cycle) | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae01210 | 2-Oxocarboxylic acid metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| PseudoCyc | GLYCOLYSIS-TCA-GLYOX-BYPASS | superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | TCA | TCA cycle I (prokaryotic) | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | FERMENTATION-PWY | mixed acid fermentation | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCyc | TCA-GLYOX-BYPASS | superpathway of glyoxylate bypass and TCA | 19.5 |
ECO:0000250
sequence similarity evidence used in manual assertion |
12867747 |
| PseudoCAP | Citrate cycle (TCA cycle) |
ECO:0000037
not_recorded |
|||
| KEGG | pae01230 | Biosynthesis of amino acids | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae01110 | Biosynthesis of secondary metabolites | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae01130 | Biosynthesis of antibiotics | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae00630 | Glyoxylate and dicarboxylate metabolism | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| FunFam | G3DSA:3.30.499.10:FF:000009 | Aconitate hydratase | - | - | 373 | 609 | 2.3E-114 |
| SUPERFAMILY | SSF52016 | LeuD/IlvD-like | - | - | 649 | 909 | 1.1E-90 |
| Gene3D | G3DSA:3.30.499.10 | Aconitase, domain 3 | IPR015931 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 | 373 | 609 | 1.7E-99 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 217 | 232 | 7.7E-42 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 512 | 525 | 7.7E-42 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 146 | 159 | 7.7E-42 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 203 | 216 | 7.7E-42 |
| Pfam | PF00694 | Aconitase C-terminal domain | IPR000573 | Aconitase A/isopropylmalate dehydratase small subunit, swivel domain | 710 | 837 | 2.0E-46 |
| CDD | cd01580 | AcnA_IRP_Swivel | IPR044137 | Aconitase A, swivel domain | 686 | 856 | 1.5261E-115 |
| Gene3D | G3DSA:3.20.19.10 | Aconitase, domain 4 | IPR015928 | Aconitase/3-isopropylmalate dehydratase, swivel | 673 | 910 | 2.0E-105 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 450 | 461 | 7.7E-42 |
| Gene3D | G3DSA:3.30.499.10 | Aconitase, domain 3 | IPR015931 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 | 6 | 372 | 0.0 |
| SUPERFAMILY | SSF53732 | Aconitase iron-sulfur domain | IPR036008 | Aconitase, iron-sulfur domain | 5 | 645 | 0.0 |
| Pfam | PF00330 | Aconitase family (aconitate hydratase) | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 74 | 581 | 0.0 |
| FunFam | G3DSA:3.20.19.10:FF:000001 | Aconitate hydratase | - | - | 672 | 910 | 3.5E-115 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 372 | 386 | 7.7E-42 |
| PANTHER | PTHR11670 | ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER | IPR006249 | Aconitase/Iron-responsive element-binding protein 2 | 14 | 909 | 0.0 |
| Gene3D | G3DSA:6.10.190.10 | - | - | - | 610 | 669 | 1.4E-23 |
| NCBIfam | TIGR01341 | JCVI: aconitate hydratase AcnA | IPR006249 | Aconitase/Iron-responsive element-binding protein 2 | 18 | 910 | 0.0 |
| FunFam | G3DSA:3.30.499.10:FF:000002 | Aconitate hydratase | - | - | 5 | 372 | 0.0 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 279 | 292 | 7.7E-42 |
| CDD | cd01586 | AcnA_IRP | - | - | 85 | 583 | 0.0 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 293 | 306 | 7.7E-42 |
| PRINTS | PR00415 | Aconitase family signature | IPR001030 | Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain | 170 | 178 | 7.7E-42 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.