Pseudomonas aeruginosa PAO1, PA1972 (eptA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1972
Name
eptA
Replicon chromosome
Genomic location 2153594 - 2155297 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs
CommentFunction demonstrated in PA14_39020 (strain UCBPP-PA14).

Cross-References

RefSeq NP_250662.1
GI 15597168
Affymetrix PA1972_at
Entrez 881487
GenBank AAG05360.1
INSDC AAG05360.1
NCBI Locus Tag PA1972
protein_id(GenBank) gb|AAG05360.1|AE004623_10|gnl|PseudoCAP|PA1972
TIGR NTL03PA01972
UniParc UPI00000C5539
UniProtKB Acc Q9I2D3
UniProtKB ID Q9I2D3_PSEAE
UniRef100 UniRef100_Q9I2D3
UniRef50 UniRef50_S2FPC3
UniRef90 UniRef90_Q9I2D3

Product

Feature Type CDS
Coding Frame 1
Product Name
lipid A phosphoethanolamine transferase, EptA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 0.08
Kyte-Doolittle Hydrophobicity Value 0.040
Molecular Weight (kDa) 62.3
Isoelectric Point (pI) 7.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 137 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003461 (883 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1972
Search term: eptA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Extracellular zinc induces phosphoethanolamine addition to Pseudomonas aeruginosa lipid A via the ColRS two-component system.
Nowicki EM, O'Brien JP, Brodbelt JS, Trent MS
Mol Microbiol 2015 Jul;97(1):166-78
PubMed ID: 25846400
Exogenous and Endogenous Phosphoethanolamine Transferases Differently Affect Colistin Resistance and Fitness in Pseudomonas aeruginosa.
Cervoni M, Lo Sciuto A, Bianchini C, Mancone C, Imperi F
Front Microbiol 2021;12:778968
PubMed ID: 34777328
Regulatory Landscape of the Pseudomonas aeruginosa Phosphoethanolamine Transferase Gene eptA in the Context of Colistin Resistance.
Cervoni M, Sposato D, Lo Sciuto A, Imperi F
Antibiotics (Basel) 2023 Jan 18;12(2)
PubMed ID: 36830112