Pseudomonas aeruginosa PAO1, PA2011 (liuE)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:0008300	isoprenoid catabolic process	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	16517656	Reviewed by curator
Biological Process	GO:0046247	terpene catabolic process	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	19459965	Reviewed by curator
Biological Process	GO:0006552	leucine catabolic process	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	19459965	Reviewed by curator
Molecular Function	GO:0004419	hydroxymethylglutaryl-CoA lyase activity	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	16517656	Reviewed by curator
Molecular Function	GO:0016833	oxo-acid-lyase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PTHR42738	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PF00682	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
PseudoCyc	LEUDEG-PWY	leucine degradation I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00281	Geraniol degradation	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00072	Synthesis and degradation of ketone bodies	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	LEU-DEG2-PWY	L-leucine degradation I	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCAP		Acyclic isoprenoid and branched-chain amino acids catabolism		ECO:0000037 not_recorded
KEGG	pae00280	Valine, leucine and isoleucine degradation	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae00650	Butanoate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
CDD	cd07938	DRE_TIM_HMGL	-	-	9	282	0.0
Gene3D	G3DSA:3.20.20.70	Aldolase class I	IPR013785	Aldolase-type TIM barrel	1	300	9.0E-121
Pfam	PF00682	HMGL-like	IPR000891	Pyruvate carboxyltransferase	6	278	3.6E-53
SUPERFAMILY	SSF51569	Aldolase	-	-	1	289	8.61E-73
FunFam	G3DSA:3.20.20.70:FF:000201	Hydroxymethylglutaryl-CoA lyase	-	-	2	300	0.0
PANTHER	PTHR42738	HYDROXYMETHYLGLUTARYL-COA LYASE	IPR043594	HMG-CoA lyase	2	298	0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.