Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2012
|
Name |
liuD
Synonym: mccA Synonym: gnyA Synonym: accA |
Replicon | chromosome |
Genomic location | 2200685 - 2202652 (- strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_250702.1 |
GI | 15597208 |
Affymetrix | PA2012_at |
Entrez | 879012 |
GenBank | AAG05400.1 |
INSDC | AAG05400.1 |
NCBI Locus Tag | PA2012 |
protein_id(GenBank) | gb|AAG05400.1|AE004627_8|gnl|PseudoCAP|PA2012 |
TIGR | NTL03PA02012 |
UniParc | UPI00000C5558 |
UniProtKB Acc | Q9I299 |
UniProtKB ID | Q9I299_PSEAE |
UniRef100 | UniRef100_Q9I299 |
UniRef50 | UniRef50_Q9I299 |
UniRef90 | UniRef90_Q9I299 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
methylcrotonyl-CoA carboxylase, alpha-subunit (biotin-containing)
|
Synonyms |
MccA alpha subunit of geranoyl-CoA carboxylase, GnyA |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -16.10 |
Kyte-Doolittle Hydrophobicity Value | -0.234 |
Molecular Weight (kDa) | 71.3 |
Isoelectric Point (pI) | 5.62 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
3U9T | LIGASE | 10/19/11 | Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme | Pseudomonas aeruginosa | 2.9 | X-RAY DIFFRACTION | 100.0 |
3U9S | LIGASE | 10/19/11 | Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, CoA complex | Pseudomonas aeruginosa | 3.5 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 643 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003427 (523 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2012
Search term: liuD
|
Ensembl
110, assembly
GRCh38.p14
|
methylcrotonyl-CoA carboxylase subunit 1 [Source:HGNC Symbol;Acc:HGNC:6936]
E-value:
4.1e-163
Percent Identity:
45.9
|
The gnyRDBHAL cluster is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa.
Díaz-Pérez AL, Zavala-Hernández AN, Cervantes C, Campos-García J
Appl Environ Microbiol 2004 Sep;70(9):5102-10
PubMed ID: 15345388
|
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D
Appl Environ Microbiol 2006 Jul;72(7):4819-28
PubMed ID: 16820476
|
Lipid synthesis in mycobacteria: characterization of the biotin carboxyl carrier protein genes from Mycobacterium leprae and M. tuberculosis.
Norman E, De Smet KA, Stoker NG, Ratledge C, Wheeler PR, Dale JW
J Bacteriol 1994 May;176(9):2525-31
PubMed ID: 7909542
|