Pseudomonas aeruginosa PAO1, PA2015 (liuA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Molecular Function	GO:0008470	isovaleryl-CoA dehydrogenase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	18625020	Reviewed by curator
Molecular Function	GO:0008470	isovaleryl-CoA dehydrogenase activity	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	16517656	Reviewed by curator
Biological Process	GO:0008300	isoprenoid catabolic process	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	16517656	Reviewed by curator
Biological Process	GO:0044248	cellular catabolic process	ISS Inferred from Sequence or Structural Similarity	ECO:0000044 sequence similarity evidence
Molecular Function	GO:0003995	acyl-CoA dehydrogenase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:cd01156	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:1.10.540.10	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	ISM Inferred from Sequence Model Term mapped from: InterPro:G3DSA:1.10.540.10	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00280	Valine, leucine and isoleucine degradation	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCAP		Acyclic isoprenoid catabolism		ECO:0000037 not_recorded
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
Pfam	PF02770	Acyl-CoA dehydrogenase, middle domain	IPR006091	Acyl-CoA oxidase/dehydrogenase, middle domain	127	222	7.8E-27
Pfam	PF00441	Acyl-CoA dehydrogenase, C-terminal domain	IPR009075	Acyl-CoA dehydrogenase/oxidase, C-terminal	234	382	4.1E-41
PIRSF	PIRSF016578	PIGM	-	-	12	387	1.2E-14
FunFam	G3DSA:2.40.110.10:FF:000004	Isovaleryl-CoA dehydrogenase, mitochondrial	-	-	126	239	4.0E-57
SUPERFAMILY	SSF47203	Acyl-CoA dehydrogenase C-terminal domain-like	IPR036250	Acyl-CoA dehydrogenase-like, C-terminal	233	385	6.28E-46
FunFam	G3DSA:1.10.540.10:FF:000022	Isovaleryl-CoA dehydrogenase isoform 2	-	-	2	124	8.4E-58
Gene3D	G3DSA:2.40.110.10	-	IPR046373	Acyl-CoA oxidase/dehydrogenase, middle domain superfamily	126	239	5.0E-43
Gene3D	G3DSA:1.10.540.10	-	IPR037069	Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily	2	124	6.0E-40
Pfam	PF02771	Acyl-CoA dehydrogenase, N-terminal domain	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal	14	123	2.3E-38
FunFam	G3DSA:1.20.140.10:FF:000003	isovaleryl-CoA dehydrogenase, mitochondrial	-	-	240	384	3.7E-80
SUPERFAMILY	SSF56645	Acyl-CoA dehydrogenase NM domain-like	IPR009100	Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily	5	247	1.2E-86
Gene3D	G3DSA:1.20.140.10	-	-	-	240	382	1.1E-46
CDD	cd01156	IVD	IPR034183	Isovaleryl-CoA dehydrogenase	9	384	0.0
PANTHER	PTHR43884	ACYL-COA DEHYDROGENASE	-	-	12	385	0.0

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.