Pseudomonas aeruginosa PAO1, PA2018 (mexY)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Molecular Function GO:0015238 drug transmembrane transporter activity
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
10543738 Reviewed by curator
Biological Process GO:0046677 response to antibiotic
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Molecular Function GO:0015238 drug transmembrane transporter activity
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
9925549 Reviewed by curator
Biological Process GO:0046677 response to antibiotic
EXP
Inferred from Experiment
ECO:0000269
experimental evidence used in manual assertion
16030228 Reviewed by curator
Biological Process GO:0046677 response to antibiotic
EXP
Inferred from Experiment
ECO:0000269
experimental evidence used in manual assertion
10952562 Reviewed by curator
Biological Process GO:0006811 ion transport
ISS
Inferred from Sequence or Structural Similarity
ECO:0000250
sequence similarity evidence used in manual assertion
Biological Process GO:0042493 response to drug
EXP
Inferred from Experiment
ECO:0000269
experimental evidence used in manual assertion
16030228 Reviewed by curator
Cellular Component GO:0016020 membrane
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0046677 response to antibiotic
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
10952562 Reviewed by curator
Biological Process GO:0006810 transport
ISS
Inferred from Sequence or Structural Similarity
ECO:0000044
sequence similarity evidence
Biological Process GO:0006810 transport
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016020 membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PF00873
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0016021 integral component of membrane
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0005215 transporter activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Transport of small molecules Other PAO1 genes in this class
Membrane proteins Other PAO1 genes in this class
Antibiotic resistance and susceptibility Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae02020 Two-component system 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01501 beta-Lactam resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
SUPERFAMILY SSF82693 135 181 1.36E-25
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 444 467 1.2E-105
SUPERFAMILY SSF82693 38 130 3.14E-24
Gene3D G3DSA:1.20.1640.10 822 1026 1.5E-36
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 335 358 1.2E-105
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 618 632 1.2E-105
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 469 492 1.2E-105
SUPERFAMILY SSF82866 295 497 8.76E-50
TIGRFAM TIGR00915 2A0602: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family IPR004764 Hydrophobe/amphiphile efflux-1 HAE1 1 1032 0.0
SUPERFAMILY SSF82693 564 667 6.02E-25
Gene3D G3DSA:3.30.70.1430 566 665 4.2E-18
Gene3D G3DSA:3.30.2090.10 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 718 806 1.4E-17
SUPERFAMILY SSF82693 273 329 1.36E-25
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 8 32 1.2E-105
Gene3D G3DSA:3.30.70.1430 38 139 4.8E-25
SUPERFAMILY SSF82714 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 181 270 4.58E-18
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 390 414 1.2E-105
SUPERFAMILY SSF82714 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 719 805 5.62E-20
Pfam PF00873 AcrB/AcrD/AcrF family IPR001036 Acriflavin resistance protein 1 1022 0.0
Gene3D G3DSA:3.30.2090.10 IPR027463 Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains 179 274 1.1E-15
Gene3D G3DSA:1.20.1640.10 285 509 2.8E-46
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 36 54 1.2E-105
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 362 383 1.2E-105
SUPERFAMILY SSF82866 803 1025 1.31E-44
PRINTS PR00702 Acriflavin resistance protein family signature IPR001036 Acriflavin resistance protein 551 568 1.2E-105

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.