Pseudomonas aeruginosa PAO1, PA2018 (mexY)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0006811 | ion transport | Inferred from Sequence or Structural Similarity | ECO:0000250 sequence similarity evidence used in manual assertion |
||
| Molecular Function | GO:0042910 | xenobiotic transmembrane transporter activity | Inferred from Direct Assay | ECO:0000314 direct assay evidence used in manual assertion |
10543738 | Reviewed by curator |
| Biological Process | GO:0046677 | response to antibiotic | Inferred from Mutant Phenotype | ECO:0000015 mutant phenotype evidence |
10952562 | Reviewed by curator |
| Biological Process | GO:0046677 | response to antibiotic | Inferred from Sequence or Structural Similarity | ECO:0000044 sequence similarity evidence |
||
| Biological Process | GO:0046677 | response to antibiotic | Inferred from Experiment | ECO:0000269 experimental evidence used in manual assertion |
16030228 | Reviewed by curator |
| Molecular Function | GO:0042910 | xenobiotic transmembrane transporter activity | Inferred from Direct Assay | ECO:0000314 direct assay evidence used in manual assertion |
9925549 | Reviewed by curator |
| Biological Process | GO:0042493 | response to drug | Inferred from Experiment | ECO:0000269 experimental evidence used in manual assertion |
16030228 | Reviewed by curator |
| Biological Process | GO:0046677 | response to antibiotic | Inferred from Experiment | ECO:0000269 experimental evidence used in manual assertion |
10952562 | Reviewed by curator |
| Cellular Component | GO:0016020 | membrane | Inferred from Sequence or Structural Similarity | ECO:0000044 sequence similarity evidence |
||
| Biological Process | GO:0006810 | transport | Inferred from Sequence or Structural Similarity | ECO:0000044 sequence similarity evidence |
||
| Biological Process | GO:0042908 | xenobiotic transport |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0015562 | efflux transmembrane transporter activity |
Inferred from Sequence Model
Term mapped from: InterPro:TIGR00915
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Cellular Component | GO:0016020 | membrane |
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0022857 | transmembrane transporter activity |
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0055085 | transmembrane transport |
Inferred from Sequence Model
Term mapped from: InterPro:PR00702
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG | pae01501 | beta-Lactam resistance | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
|
| KEGG | pae02020 | Two-component system | 81.0+/01-23, Jan 17 |
ECO:0000249
sequence similarity evidence used in automatic assertion |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 618 | 632 | 1.2E-105 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 8 | 32 | 1.2E-105 |
| SUPERFAMILY | SSF82714 | Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | IPR027463 | Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains | 181 | 270 | 4.58E-18 |
| NCBIfam | TIGR00915 | JCVI: efflux RND transporter permease subunit | IPR004764 | Multidrug resistance protein MdtF-like | 1 | 1032 | 0.0 |
| Gene3D | G3DSA:3.30.70.1440 | Multidrug efflux transporter AcrB pore domain | - | - | 669 | 867 | 0.0 |
| Gene3D | G3DSA:3.30.2090.10 | Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | IPR027463 | Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains | 179 | 277 | 0.0 |
| SUPERFAMILY | SSF82866 | Multidrug efflux transporter AcrB transmembrane domain | - | - | 803 | 1025 | 1.31E-44 |
| Gene3D | G3DSA:3.30.70.1320 | Multidrug efflux transporter AcrB pore domain like | - | - | 132 | 330 | 0.0 |
| Gene3D | G3DSA:3.30.70.1430 | Multidrug efflux transporter AcrB pore domain | - | - | 38 | 817 | 0.0 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 36 | 54 | 1.2E-105 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 469 | 492 | 1.2E-105 |
| PANTHER | PTHR32063 | - | IPR001036 | Acriflavin resistance protein | 2 | 1029 | 0.0 |
| SUPERFAMILY | SSF82693 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | - | - | 38 | 130 | 3.14E-24 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 444 | 467 | 1.2E-105 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 551 | 568 | 1.2E-105 |
| SUPERFAMILY | SSF82693 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | - | - | 135 | 329 | 1.36E-25 |
| FunFam | G3DSA:3.30.70.1430:FF:000001 | Efflux pump membrane transporter | - | - | 38 | 137 | 1.1E-26 |
| SUPERFAMILY | SSF82714 | Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | IPR027463 | Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains | 719 | 805 | 5.62E-20 |
| Gene3D | G3DSA:3.30.2090.10 | Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains | IPR027463 | Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains | 721 | 809 | 0.0 |
| Gene3D | G3DSA:1.20.1640.10 | Multidrug efflux transporter AcrB transmembrane domain | - | - | 515 | 1019 | 0.0 |
| SUPERFAMILY | SSF82693 | Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains | - | - | 564 | 667 | 6.02E-25 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 335 | 358 | 1.2E-105 |
| SUPERFAMILY | SSF82866 | Multidrug efflux transporter AcrB transmembrane domain | - | - | 295 | 497 | 8.76E-50 |
| Pfam | PF00873 | AcrB/AcrD/AcrF family | IPR001036 | Acriflavin resistance protein | 1 | 1022 | 0.0 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 390 | 414 | 1.2E-105 |
| Gene3D | G3DSA:1.20.1640.10 | Multidrug efflux transporter AcrB transmembrane domain | - | - | 7 | 514 | 0.0 |
| PRINTS | PR00702 | Acriflavin resistance protein family signature | IPR001036 | Acriflavin resistance protein | 362 | 383 | 1.2E-105 |
| FunFam | G3DSA:1.20.1640.10:FF:000001 | Efflux pump membrane transporter | - | - | 322 | 509 | 3.0E-72 |
| Gene3D | G3DSA:3.30.70.1430 | Multidrug efflux transporter AcrB pore domain | - | - | 569 | 668 | 0.0 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.