Pseudomonas aeruginosa PAO1, PA2409 (fpvE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2409
Name
fpvE
Replicon chromosome
Genomic location 2691862 - 2692767 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
CommentPart ABC transporter complex FpvWXYZCDEF coded by operons fpvWXYZCDEF and fpvF.

Cross-References

RefSeq NP_251099.1
GI 15597605
Affymetrix PA2409_at
DNASU PaCD00007048
Entrez 879638
GenBank AAG05797.1
INSDC AAG05797.1
NCBI Locus Tag PA2409
protein_id(GenBank) gb|AAG05797.1|AE004668_7|gnl|PseudoCAP|PA2409
TIGR NTL03PA02409
UniParc UPI00000C56B8
UniProtKB Acc Q9I172
UniProtKB ID Q9I172_PSEAE
UniRef100 UniRef100_W0Z6N2
UniRef50 UniRef50_Q884F4
UniRef90 UniRef90_W0Z6N2

Product

Feature Type CDS
Coding Frame 1
Product Name
FpvE
Product Name Confidence: Class 1
Synonyms probable permease of ABC transporter
Evidence for Translation
Charge (pH 7) 4.85
Kyte-Doolittle Hydrophobicity Value 1.210
Molecular Weight (kDa) 31.0
Isoelectric Point (pI) 9.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 508 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003123 (477 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2409
Search term: fpvE
Search term: FpvE

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH.
Ganne G, Brillet K, Basta B, Roche B, Hoegy F, Gasser V, Schalk IJ
ACS Chem Biol 2017 Apr 21;12(4):1056-1065
PubMed ID: 28192658
An ABC transporter with two periplasmic binding proteins involved in iron acquisition in Pseudomonas aeruginosa.
Brillet K, Ruffenach F, Adams H, Journet L, Gasser V, Hoegy F, Guillon L, Hannauer M, Page A, Schalk IJ
ACS Chem Biol 2012 Dec 21;7(12):2036-45
PubMed ID: 23009327
The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions.
Gao L, Guo Z, Wang Y, Wang Y, Wang K, Li B, Shen L
J Membr Biol 2018 Feb;251(1):91-104
PubMed ID: 28975384