Pseudomonas aeruginosa PAO1, PA2634 (aceA)

Gene Ontology

Ontology	Accession	Term	GO Evidence	Evidence Ontology (ECO) Code	Reference	Comments
Biological Process	GO:1900232	negative regulation of single-species biofilm formation on inanimate substrate	IMP Inferred from Mutant Phenotype	ECO:0000015 mutant phenotype evidence	23363478	Reviewed by curator
Biological Process	GO:0009405	pathogenesis	IMP Inferred from Mutant Phenotype	ECO:0000315 mutant phenotype evidence used in manual assertion	18524916	Reviewed by curator
Molecular Function	GO:0004451	isocitrate lyase activity	IDA Inferred from Direct Assay	ECO:0000314 direct assay evidence used in manual assertion	17319879	Reviewed by curator
Biological Process	GO:0019752	carboxylic acid metabolic process	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF001362	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0003824	catalytic activity	ISM Inferred from Sequence Model Term mapped from: InterPro:cd00377	ECO:0000259 match to InterPro signature evidence used in automatic assertion
Molecular Function	GO:0004451	isocitrate lyase activity	ISM Inferred from Sequence Model Term mapped from: InterPro:PIRSF001362	ECO:0000259 match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Putative enzymes Other PAO1 genes in this class

Pathways

Database	Xref	Pathway	Version	Evidence	PMID
KEGG	pae00630	Glyoxylate and dicarboxylate metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01200	Carbon metabolism	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
KEGG	pae01100	Metabolic pathways	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
PseudoCyc	P106-PWY	serine-isocitrate lyase pathway	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	TCA-GLYOX-BYPASS	superpathway of glyoxylate bypass and TCA	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	GLYCOLYSIS-TCA-GLYOX-BYPASS	superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
PseudoCyc	GLYOXYLATE-BYPASS	glyoxylate cycle	19.5	ECO:0000250 sequence similarity evidence used in manual assertion	12867747
KEGG	pae01120	Microbial metabolism in diverse environments	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion
MetaCyc		TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)	InterPro 5.36-75.0	ECO:0000259 match to InterPro signature evidence used in automatic assertion
KEGG	pae01110	Biosynthesis of secondary metabolites	81.0+/01-23, Jan 17	ECO:0000249 sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis	Accession	Description	Interpro Accession	Interpro Description	Amino Acid Start	Amino Acid Stop	E-value
PIRSF	PIRSF001362	ICL	IPR006254	Isocitrate lyase	1	277	7.7E-29
PANTHER	PTHR21631	ISOCITRATE LYASE/MALATE SYNTHASE	IPR006254	Isocitrate lyase	2	531	2.8E-130
CDD	cd00377	ICL_PEPM	IPR039556	ICL/PEPM domain	63	386	4.5747E-34
Pfam	PF00463	Isocitrate lyase family	IPR006254	Isocitrate lyase	429	530	2.8E-13
Pfam	PF00463	Isocitrate lyase family	IPR006254	Isocitrate lyase	330	399	1.3E-9
SUPERFAMILY	SSF51621	Phosphoenolpyruvate/pyruvate domain	IPR015813	Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily	10	514	4.93E-124
Gene3D	G3DSA:3.20.20.60	-	IPR040442	Pyruvate kinase-like domain superfamily	2	531	1.0E-128
PIRSF	PIRSF001362	ICL	IPR006254	Isocitrate lyase	294	410	1.0E-11
Pfam	PF00463	Isocitrate lyase family	IPR006254	Isocitrate lyase	81	269	3.5E-20
PIRSF	PIRSF001362	ICL	IPR006254	Isocitrate lyase	412	531	5.9E-8

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.