Pseudomonas aeruginosa PAO1, PA3488 (tli5)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3488
Name
tli5
Synonym: tli5a
Replicon chromosome
Genomic location 3905959 - 3907089 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252178
GI 15598684
Affymetrix PA3488_at
Entrez 880041
GenBank AAG06876.1
NCBI Locus Tag PA3488
protein_id(GenBank) gb|AAG06876.1|AE004770_1|gnl|PseudoCAP|PA3488
TIGR NTL03PA03488
UniProtKB Acc Q9HYC1
UniProtKB ID Q9HYC1_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
Tli5
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.17
Kyte-Doolittle Hydrophobicity Value -0.570
Molecular Weight (kDa) 26.6
Isoelectric Point (pI) 9.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7WDK IMMUNE SYSTEM 12/21/21 The structure of PldA-PA3488 complex Pseudomonas aeruginosa; Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 3.05 ELECTRON MICROSCOPY 100.0
5XMG IMMUNE SYSTEM 05/15/17 Crystal structure of PA3488 from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.8 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 5 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002155 (81 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3488
Search term: tli5
Search term: Tli5

Human Homologs

References

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.
Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD
Nature 2013 Apr 25;496(7446):508-12
PubMed ID: 23552891
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999
The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting.
Sana TG, Berni B, Bleves S
Front Cell Infect Microbiol 2016;6:61
PubMed ID: 27376031