Pseudomonas aeruginosa PAO1, PA5016 (aceF)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0006096 glycolytic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0015976 carbon utilization
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0006090 pyruvate metabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0006094 gluconeogenesis
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0006091 generation of precursor metabolites and energy
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000044
sequence similarity evidence
Biological Process GO:0044248 cellular catabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Molecular Function GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01348
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0016746 transferase activity, transferring acyl groups
ISM
Inferred from Sequence Model
Term mapped from: InterPro:SSF47005
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Cellular Component GO:0045254 pyruvate dehydrogenase complex
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01348
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0006096 glycolytic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:TIGR01348
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Energy metabolism Other PAO1 genes in this class
Carbon compound catabolism Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Pyruvate metabolism ECO:0000037
not_recorded
PseudoCyc ANARESP1-PWY anaerobic respiration 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00620 Pyruvate metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc P41-PWY pyruvate fermentation to acetate and lactate I 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae00020 Citrate cycle (TCA cycle) 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00010 Glycolysis / Gluconeogenesis 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-5482 pyruvate fermentation to acetate II 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
PseudoCyc GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01120 Microbial metabolism in diverse environments 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01200 Carbon metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01130 Biosynthesis of antibiotics 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCAP Glycolysis / Gluconeogenesis ECO:0000037
not_recorded
PseudoCyc LCTACACAT-PWY lactate oxidation 19.5 ECO:0000250
sequence similarity evidence used in manual assertion 		12867747
KEGG pae01110 Biosynthesis of secondary metabolites 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
FunFam G3DSA:3.30.559.10:FF:000004 Acetyltransferase component of pyruvate dehydrogenase complex - - 302 547 2.1E-119
CDD cd06849 lipoyl_domain - - 5 74 3.27932E-22
MobiDBLite mobidb-lite consensus disorder prediction - - 202 248 -
FunFam G3DSA:2.40.50.100:FF:000009 Acetyltransferase component of pyruvate dehydrogenase complex - - 118 198 5.6E-30
Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain 318 546 1.6E-76
SUPERFAMILY SSF51230 Single hybrid motif IPR011053 Single hybrid motif 4 93 4.06E-23
FunFam G3DSA:4.10.320.10:FF:000003 Acetyltransferase component of pyruvate dehydrogenase complex - - 247 292 9.5E-24
MobiDBLite mobidb-lite consensus disorder prediction - - 75 117 -
SUPERFAMILY SSF51230 Single hybrid motif IPR011053 Single hybrid motif 118 212 6.41E-23
Gene3D G3DSA:2.40.50.100 - - - 2 79 3.7E-25
Pfam PF02817 e3 binding domain IPR004167 Peripheral subunit-binding domain 247 282 8.2E-15
PANTHER PTHR43178 DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX - - 5 108 0.0
CDD cd06849 lipoyl_domain - - 120 192 2.19733E-19
FunFam G3DSA:2.40.50.100:FF:000009 Acetyltransferase component of pyruvate dehydrogenase complex - - 1 80 1.7E-30
SUPERFAMILY SSF52777 CoA-dependent acyltransferases - - 306 547 9.78E-80
NCBIfam TIGR01348 JCVI: dihydrolipoyllysine-residue acetyltransferase IPR006256 Dihydrolipoamide acetyltransferase pyruvate dehydrogenase complex 4 547 0.0
Gene3D G3DSA:2.40.50.100 - - - 120 198 2.0E-22
Pfam PF00364 Biotin-requiring enzyme IPR000089 Biotin/lipoyl attachment 5 74 9.9E-23
Pfam PF00364 Biotin-requiring enzyme IPR000089 Biotin/lipoyl attachment 121 192 4.7E-23
Gene3D G3DSA:4.10.320.10 - IPR036625 E3-binding domain superfamily 247 292 4.7E-17
Gene3D G3DSA:3.30.559.10 - IPR023213 Chloramphenicol acetyltransferase-like domain superfamily 305 547 4.8E-87
SUPERFAMILY SSF47005 Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex IPR036625 E3-binding domain superfamily 242 286 4.97E-12

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.