Pseudomonas aeruginosa PAO1, PA5087 (tli5b2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5087
Name
tli5b2
Replicon chromosome
Genomic location 5725479 - 5726348 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_253774.1
GI 15600280
Affymetrix PA5087_at
Entrez 882273
GenBank AAG08472.1
NCBI Locus Tag PA5087
protein_id(GenBank) gb|AAG08472.1|AE004921_9|gnl|PseudoCAP|PA5087
TIGR NTL03PA05088
UniProtKB Acc Q9HU96
UniProtKB ID Q9HU96_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion lipase immunity protein, Tli5b2
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 0.86
Kyte-Doolittle Hydrophobicity Value -0.344
Molecular Weight (kDa) 32.1
Isoelectric Point (pI) 7.48

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5JKP IMMUNE SYSTEM 04/26/16 Crystal structure of immunity protein Pa5087 from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.106 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 96 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000351 (1065 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5087
Search term: tli5b2

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The T6SSs of Pseudomonas aeruginosa Strain PAO1 and Their Effectors: Beyond Bacterial-Cell Targeting.
Sana TG, Berni B, Bleves S
Front Cell Infect Microbiol 2016;6:61
PubMed ID: 27376031