Pseudomonas aeruginosa PAO1, PA5453 (gmd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0019306 GDP-D-rhamnose biosynthetic process
EXP
Inferred from Experiment
ECO:0000269
experimental evidence used in manual assertion
19459932 Reviewed by curator
Biological Process GO:0009243 O antigen biosynthetic process
IDA
Inferred from Direct Assay
ECO:0000314
direct assay evidence used in manual assertion
19459932 Reviewed by curator
Biological Process GO:0009103 lipopolysaccharide biosynthetic process
IMP
Inferred from Mutant Phenotype
ECO:0000015
mutant phenotype evidence
8548534 Reviewed by curator
Molecular Function GO:0008446 GDP-mannose 4,6-dehydratase activity
EXP
Inferred from Experiment
ECO:0000269
experimental evidence used in manual assertion
9781879 Reviewed by curator
Molecular Function GO:0008446 GDP-mannose 4,6-dehydratase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43715
ECO:0000259
match to InterPro signature evidence used in automatic assertion
Biological Process GO:0019673 GDP-mannose metabolic process
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PTHR43715
ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Cell wall / LPS / capsule Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
KEGG pae00051 Fructose and mannose metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc COLANSYN-PWY colanic acid building blocks biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
PseudoCAP Fructose and mannose metabolism ECO:0000037
not_recorded
PseudoCAP Lipopolysaccharide biosynthesis ECO:0000037
not_recorded
PseudoCyc GDPRHAMSYN-PWY GDP-D-rhamnose biosynthesis 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747
KEGG pae01100 Metabolic pathways 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae00520 Amino sugar and nucleotide sugar metabolism 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
PseudoCyc PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 19.5 ECO:0000250
sequence similarity evidence used in manual assertion
12867747

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Pfam PF16363 GDP-mannose 4,6 dehydratase IPR016040 NAD(P)-binding domain 6 312 9.6E-123
Gene3D G3DSA:3.90.25.10 - - - 186 312 0.0
PANTHER PTHR43715 GDP-MANNOSE 4,6-DEHYDRATASE IPR006368 GDP-mannose 4,6-dehydratase 3 320 1.2E-121
Gene3D G3DSA:3.40.50.720 - - - 6 302 0.0
FunFam G3DSA:3.40.50.720:FF:000924 GDP-mannose 4,6 dehydratase - - 1 208 5.5E-61
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains IPR036291 NAD(P)-binding domain superfamily 3 319 9.68E-75
CDD cd05260 GDP_MD_SDR_e - - 5 318 0.0
Hamap MF_00955 GDP-mannose 4,6-dehydratase [gmd]. IPR006368 GDP-mannose 4,6-dehydratase 3 322 53.110771
NCBIfam TIGR01472 JCVI: GDP-mannose 4,6-dehydratase IPR006368 GDP-mannose 4,6-dehydratase 4 319 8.0E-127

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.