Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA5453
|
Name |
gmd
Synonym: gca Synonym: lpsA |
Replicon | chromosome |
Genomic location | 6143109 - 6144080 (- strand) |
Transposon Mutants | 5 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_254140.1 |
GI | 15600646 |
Affymetrix | PA5453_gmd_at |
DNASU | PaCD00008350 |
Entrez | 883089 |
GenBank | AAG08838.1 |
INSDC | AAG08838.1 |
NCBI Locus Tag | PA5453 |
protein_id(GenBank) | gb|AAG08838.1|AE004958_8|gnl|PseudoCAP|PA5453 |
TIGR | NTL03PA05454 |
UniParc | UPI000012B8A1 |
UniProtKB Acc | Q51366 |
UniProtKB ID | GM4D_PSEAE |
UniRef100 | UniRef100_Q51366 |
UniRef50 | UniRef50_Q51366 |
UniRef90 | UniRef90_Q51366 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
GDP-mannose 4,6-dehydratase
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -1.61 |
Kyte-Doolittle Hydrophobicity Value | -0.291 |
Molecular Weight (kDa) | 36.4 |
Isoelectric Point (pI) | 6.53 |
Individual Mappings | |
Additional evidence for subcellular localization |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
1RPN | LYASE | 12/03/03 | Crystal Structure of GDP-D-mannose 4,6-dehydratase in complexes with GDP and NADPH | Pseudomonas aeruginosa | 2.15 | X-RAY DIFFRACTION | 100.0 |
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
Guanosine-5'-Diphosphate | DB04315 | DrugBank | 5.1.4 | Q51366 | GDP-mannose 4,6-dehydratase | 100.0 | 323 | 1.3e-186 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 611 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG004999 (381 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA5453
Search term: gmd
Search term: GDP-mannose 4,6-dehydratase
|
Ensembl
110, assembly
GRCh38.p14
|
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value:
3.1e-87
Percent Identity:
48.2
|
Chromosomal mapping, expression and synthesis of lipopolysaccharide in Pseudomonas aeruginosa: a role for guanosine diphospho (GDP)-D-mannose.
Lightfoot J, Lam JS
Mol Microbiol 1993 May;8(4):771-82
PubMed ID: 7687320
|
Prevalence of gca, a gene involved in synthesis of A-band common antigen polysaccharide in Pseudomonas aeruginosa.
Currie HL, Lightfoot J, Lam JS
Clin Diagn Lab Immunol 1995 Sep;2(5):554-62
PubMed ID: 8548534
|