Pseudomonas aeruginosa UCBPP-PA14, PA14_33970 (tpe2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_33970
Name
tpe2
Synonym: type VI peptidase effector
Replicon chromosome
Genomic location 3019627 - 3020694 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
CommentHcp Secretion Island-III-encoded type VI secretion system (H3-T6SS)

Cross-References

RefSeq YP_790870.1
GI 116050313
Entrez 4380434
INSDC ABJ11549.1
NCBI Locus Tag PA14_33970
UniParc UPI000045D2D8
UniProtKB Acc Q02MG6
UniProtKB ID Q02MG6_PSEAB
UniRef100 UniRef100_Q02MG6
UniRef50 UniRef50_Q02MG6
UniRef90 UniRef90_Q02MG6

Product

Feature Type CDS
Coding Frame 1
Product Name
Tpe2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -1.25
Kyte-Doolittle Hydrophobicity Value -0.474
Molecular Weight (kDa) 39.6
Isoelectric Point (pI) 6.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 19497948

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 2 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG014885 (151 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_33970
Search term: tpe2
Search term: Tpe2

Human Homologs

References

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading) 2009 Sep;155(Pt 9):2845-2855
PubMed ID: 19497948
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999
Diversity and prevalence of type VI secretion system effectors in clinical Pseudomonas aeruginosa isolates.
Robinson LA, Collins ACZ, Murphy RA, Davies JC, Allsopp LP
Front Microbiol 2022;13:1042505
PubMed ID: 36687572