Strain |
Pseudomonas aeruginosa PA7
GCF_000017205.1|latest |
Locus Tag |
PSPA7_4642
|
Name |
exlA
Synonym: exolysin |
Replicon | chromosome |
Genomic location | 4766323 - 4771278 (+ strand) |
RefSeq | YP_001349986.1 |
GI | 152989608 |
Entrez | 5354208 |
INSDC | ABR86791.1 |
NCBI Locus Tag | PSPA7_4642 |
UniParc | UPI0000D72521 |
UniProtKB Acc | A6VAA1 |
UniProtKB ID | A6VAA1_PSEA7 |
UniRef100 | UniRef100_A6VAA1 |
UniRef50 | UniRef50_A0A0B7DBC5 |
UniRef90 | UniRef90_A6VAA1 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
ExlA
|
Synonyms |
hemolysin |
Evidence for Translation | |
Charge (pH 7) | 0.85 |
Kyte-Doolittle Hydrophobicity Value | -0.549 |
Molecular Weight (kDa) | 171649.6 |
Isoelectric Point (pI) | 7.07 |
Individual Mappings | |
Additional evidence for subcellular localization |
Source 1 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000011
genetic interaction evidence
|
Host Organism | Homo sapiens |
Notes | Induces cell retraction, actin cytoskeleton disorganization, and cell-cell junction disruption in HUVECs. |
Infection model | LDH cytotoxicity assay in human umbilical vein endothelial cells (HUVEC) |
Reference | 24528863 |
Source 2 | |
Database | PseudoCAP |
Category | |
Evidence |
ECO:0000011
genetic interaction evidence
|
Host Organism | Mus musculus |
Notes | Leads to lethal lung hemorrhage in a mouse model of acute pneumonia. |
Infection model | Mouse model of acute pneumonia |
Reference | 24528863 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 68 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG022933 (49 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PSPA7_4642
Search term: exlA
Search term: ExlA
|
A type III secretion negative clinical strain of Pseudomonas aeruginosa employs a two-partner secreted exolysin to induce hemorrhagic pneumonia.
Elsen S, Huber P, Bouillot S, Couté Y, Fournier P, Dubois Y, Timsit JF, Maurin M, Attrée I
Cell Host Microbe 2014 Feb 12;15(2):164-76
PubMed ID: 24528863
|
ExlA: A New Contributor to Pseudomonas aeruginosa Virulence.
Huber P
Front Cell Infect Microbiol 2022;12:929150
PubMed ID: 35811671
|
Genomic erosion and horizontal gene transfer shape functional differences of the ExlA toxin in Pseudomonas spp.
Job V, Gomez-Valero L, Renier A, Rusniok C, Bouillot S, Chenal-Francisque V, Gueguen E, Adrait A, Robert-Genthon M, Jeannot K, Panchev P, Elsen S, Fauvarque MO, Couté Y, Buchrieser C, Attrée I
iScience 2022 Jul 15;25(7):104596
PubMed ID: 35789842
|
Pseudomonas aeruginosa Pore-Forming Exolysin and Type IV Pili Cooperate To Induce Host Cell Lysis.
Basso P, Ragno M, Elsen S, Reboud E, Golovkine G, Bouillot S, Huber P, Lory S, Faudry E, Attrée I
mBio 2017 Jan 24;8(1)
PubMed ID: 28119472
|
Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation.
Reboud E, Bouillot S, Patot S, Béganton B, Attrée I, Huber P
PLoS Pathog 2017 Aug;13(8):e1006579
PubMed ID: 28832671
|