Pseudomonas stutzeri A1501, PST_0399

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas stutzeri A1501
GCF_000013785.1|latest
Locus Tag
PST_0399
Name
Synonym: D2HGDH
Replicon chromosome
Genomic location 452104 - 453498 (+ strand)

Cross-References

RefSeq YP_001170947.1
GI 146280794
Entrez 5094894
INSDC ABP78105.1
NCBI Locus Tag PST_0399
UniParc UPI00014FE8CA
UniProtKB Acc A4VGK4
UniProtKB ID A4VGK4_PSEU5
UniRef100 UniRef100_A4VGK4
UniRef50 UniRef50_A0A077SBA9
UniRef90 UniRef90_A4VGK4

Product

Feature Type CDS
Coding Frame 1
Product Name
D-2-hydroxyglutarate dehydrogenase
Product Name Confidence: Class 1
Synonyms oxidoreductase, FAD-binding
Evidence for Translation
Charge (pH 7) -17.94
Kyte-Doolittle Hydrophobicity Value -0.101
Molecular Weight (kDa) 51.1
Isoelectric Point (pI) 4.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 547 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000314 (528 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PST_0399

Human Homologs

Ensembl 110, assembly GRCh38.p14
D-2-hydroxyglutarate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:28358]
E-value: 1.6e-76
Percent Identity: 35.3

References

Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.
Zhang W, Zhang M, Gao C, Zhang Y, Ge Y, Guo S, Guo X, Zhou Z, Liu Q, Zhang Y, Ma C, Tao F, Xu P
Proc Natl Acad Sci U S A 2017 Sep 5;114(36):E7574-E7582
PubMed ID: 28827360