Pseudomonas aeruginosa PAO1, PA0602

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0602
Name
Replicon chromosome
Genomic location 663515 - 664549 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentStructural similarity to 4I1D (ABC transporter substrate-binding protein from Bradyrhizobium japonicum, root-mean-square deviation: 0.8 angstroms). Sequence similarity to 4EUO (91%/33,44%) (ABU). Final predicted ligand: gamma-aminobutyric acid (PMID: 31631799)

Cross-References

RefSeq NP_249293.1
GI 15595799
Affymetrix PA0602_at
DNASU PaCD00006264
Entrez 880771
GenBank AAG03991.1
INSDC AAG03991.1
NCBI Locus Tag PA0602
protein_id(GenBank) gb|AAG03991.1|AE004496_7|gnl|PseudoCAP|PA0602
TIGR NTL03PA00603
UniParc UPI00000C50D2
UniProtKB Acc Q9I5T6
UniProtKB ID Q9I5T6_PSEAE
UniRef100 UniRef100_A0A072ZQF2
UniRef50 UniRef50_A9QZV4
UniRef90 UniRef90_A0A086C223

Product

Feature Type CDS
Coding Frame 1
Product Name
probable binding protein component of ABC transporter
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) 0.87
Kyte-Doolittle Hydrophobicity Value -0.177
Molecular Weight (kDa) 37.8
Isoelectric Point (pI) 7.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 142 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000585 (305 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0602

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach.
Caprari S, Brandi V, Pasquadibisceglie A, Polticelli F
J Biomol Struct Dyn 2020 Sep;38(15):4508-4520
PubMed ID: 31631799