Pseudomonas aeruginosa PAO1, PA0706 (cat)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0706
Name
cat
Replicon chromosome
Genomic location 779463 - 780101 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_249397.1
GI 15595903
Affymetrix PA0706_cat_at
DNASU PaCD00006322
Entrez 878374
GenBank AAG04095.1
INSDC -
NCBI Locus Tag PA0706
protein_id(GenBank) gb|AAG04095.1|AE004506_5|gnl|PseudoCAP|PA0706
TIGR NTL03PA00707
UniParc UPI000012703F
UniProtKB Acc P26841
UniProtKB ID CAT4_PSEAE
UniRef100 UniRef100_P26841
UniRef50 UniRef50_P26841
UniRef90 UniRef90_P26841

Product

Feature Type CDS
Coding Frame 1
Product Name
chloramphenicol acetyltransferase
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -4.18
Kyte-Doolittle Hydrophobicity Value -0.196
Molecular Weight (kDa) 23.5
Isoelectric Point (pI) 6.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff E-value Percent Identity CARD Version
catB7 catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa ARO:3002679 protein homolog model Perfect 0.0 1.0 1.1.8

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1XAT ACETYLTRANSFERASE 03/11/98 STRUCTURE OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA PSEUDOMONAS AERUGINOSA 3.2 X-RAY DIFFRACTION 98.6
2XAT ACETYLTRANSFERASE 03/11/98 COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A PSEUDOMONAS AERUGINOSA 3.2 X-RAY DIFFRACTION 98.6

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Desulfo-Coenzyme A DB01829 DrugBank 5.0.6 P26841 Chloramphenicol acetyltransferase 100.0 212 2.1e-125

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 396 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000683 (893 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0706
Search term: cat

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 34099
Genomic Position 779586
Position in ORF 124(639)
Reference 14617778
Type ISlacZ/hah insertion site
Mutant ID UWGC: 19505
Genomic Position 779735
Position in ORF 273(639)
Reference 14617778

Transposon Insertions in Orthologs

References

Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa.
Beaman TW, Sugantino M, Roderick SL
Biochemistry 1998 May;37(19):6689-96
PubMed ID: 9578552