Pseudomonas aeruginosa PAO1, PA0706 (cat)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA0706
Name
cat
Replicon chromosome
Genomic location 779463 - 780101 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249397.1
GI 15595903
Affymetrix PA0706_cat_at
DNASU PaCD00006322
Entrez 878374
GenBank AAG04095.1
INSDC -
NCBI Locus Tag PA0706
protein_id(GenBank) gb|AAG04095.1|AE004506_5|gnl|PseudoCAP|PA0706
TIGR NTL03PA00707
UniParc UPI000012703F
UniProtKB Acc P26841
UniProtKB ID CAT4_PSEAE
UniRef100 UniRef100_P26841
UniRef50 UniRef50_P26841
UniRef90 UniRef90_P26841

Product

Feature Type CDS
Coding Frame 1
Product Name
chloramphenicol acetyltransferase
Product Name Confidence: Class 1
Synonyms xenobiotic acetyltransferase
Evidence for Translation
Charge (pH 7) -4.18
Kyte-Doolittle Hydrophobicity Value -0.196
Molecular Weight (kDa) 23.5
Isoelectric Point (pI) 6.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff E-value Percent Identity CARD Version
catB7 catB7 is a chromosome-encoded variant of the cat gene found in Pseudomonas aeruginosa ARO:3002679 protein homolog model Perfect 0.0 1.0 1.1.8

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2XAT ACETYLTRANSFERASE 03/11/98 COMPLEX OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE WITH CHLORAMPHENICOL AND DESULFO-COENZYME A PSEUDOMONAS AERUGINOSA 3.2 X-RAY DIFFRACTION 98.6
1XAT ACETYLTRANSFERASE 03/11/98 STRUCTURE OF THE HEXAPEPTIDE XENOBIOTIC ACETYLTRANSFERASE FROM PSEUDOMONAS AERUGINOSA PSEUDOMONAS AERUGINOSA 3.2 X-RAY DIFFRACTION 98.6

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Desulfo-Coenzyme A DB01829 DrugBank 5.0.6 P26841 Chloramphenicol acetyltransferase 100.0 212 2.1e-125

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 396 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000683 (893 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0706
Search term: cat

References

Structure of the hexapeptide xenobiotic acetyltransferase from Pseudomonas aeruginosa.
Beaman TW, Sugantino M, Roderick SL
Biochemistry 1998 May;37(19):6689-96
PubMed ID: 9578552