Pseudomonas aeruginosa PAO1, PA0835 (pta)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0835
Name
pta
Replicon chromosome
Genomic location 909418 - 911532 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249526.1
GI 15596032
Affymetrix PA0835_pta_at
Entrez 882123
GenBank AAG04224.1
INSDC AAG04224.1
NCBI Locus Tag PA0835
protein_id(GenBank) gb|AAG04224.1|AE004518_5|gnl|PseudoCAP|PA0835
TIGR NTL03PA00836
UniParc UPI00000C517E
UniProtKB Acc Q9I5A5
UniProtKB ID PTA_PSEAE
UniRef100 UniRef100_Q9I5A5
UniRef50 UniRef50_Q9I5A5
UniRef90 UniRef90_Q9I5A5

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphate acetyltransferase
Product Name Confidence: Class 1
Synonyms phosphotransacetylase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -14.30
Kyte-Doolittle Hydrophobicity Value 0.015
Molecular Weight (kDa) 75.7
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 475 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000803 (528 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0835
Search term: pta

Human Homologs

References

Long-term anaerobic survival of the opportunistic pathogen Pseudomonas aeruginosa via pyruvate fermentation.
Eschbach M, Schreiber K, Trunk K, Buer J, Jahn D, Schobert M
J Bacteriol 2004 Jul;186(14):4596-604
PubMed ID: 15231792
Identification and characterization of the ackA (acetate kinase A)-pta (phosphotransacetylase) operon and complementation analysis of acetate utilization by an ackA-pta deletion mutant of Escherichia coli.
Kakuda H, Hosono K, Shiroishi K, Ichihara S
J Biochem 1994 Oct;116(4):916-22
PubMed ID: 7883769
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994