Pseudomonas aeruginosa PAO1, PA1027 (amaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1027
Name
amaB
Synonym: pcd
Replicon chromosome
Genomic location 1113129 - 1114718 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249718.1
GI 15596224
Affymetrix PA1027_at
Entrez 878608
GenBank AAG04416.1
INSDC AAG04416.1
NCBI Locus Tag PA1027
protein_id(GenBank) gb|AAG04416.1|AE004535_3|gnl|PseudoCAP|PA1027
TIGR NTL03PA01028
UniParc UPI00000C520F
UniProtKB Acc Q9I4U7
UniProtKB ID Q9I4U7_PSEAE
UniRef100 UniRef100_Q9I4U7
UniRef50 UniRef50_Q9DBF1
UniRef90 UniRef90_W0WL03

Product

Feature Type CDS
Coding Frame 1
Product Name
delta1-Piperideine-6-carboxylate dehydrogenase
Product Name Confidence: Class 2
Synonyms probable aldehyde dehydrogenase
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.02
Kyte-Doolittle Hydrophobicity Value -0.203
Molecular Weight (kDa) 57.3
Isoelectric Point (pI) 6.79

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 596 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000989 (497 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1027
Search term: amaB

Human Homologs

Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 7 family member A1 [Source:HGNC Symbol;Acc:HGNC:877]
E-value: 1.0e-124
Percent Identity: 50.0

References

Multiple and interconnected pathways for L-lysine catabolism in Pseudomonas putida KT2440.
Revelles O, Espinosa-Urgel M, Fuhrer T, Sauer U, Ramos JL
J Bacteriol 2005 Nov;187(21):7500-10
PubMed ID: 16237033