Pseudomonas aeruginosa PAO1, PA4221 (fptA)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
Replicon chromosome
Genomic location 4724639 - 4726801 (- strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs


RefSeq NP_252911.1
GI 15599417
Affymetrix PA4221_fptA_at
Entrez 880419
GenBank AAG07609.1
INSDC AAG07609.1
NCBI Locus Tag PA4221
protein_id(GenBank) gb|AAG07609.1|AE004839_2|gnl|PseudoCAP|PA4221
UniParc UPI000012ABC9
UniProtKB Acc P42512
UniRef100 UniRef100_P42512
UniRef50 UniRef50_P42512
UniRef90 UniRef90_P42512


Feature Type CDS
Coding Frame 1
Product Name
Fe(III)-pyochelin outer membrane receptor precursor
Product Name Confidence: Class 1
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Verified using two-dimensional gel electrophoresis, MALDI-TOF MS and peptide mass mapping(pI:5.9, molecular weight:80.0, PMID:21674802)
Charge (pH 7) -4.85
Kyte-Doolittle Hydrophobicity Value -0.554
Molecular Weight (kDa) 80.0
Isoelectric Point (pI) 6.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 1
Outer Membrane Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1XKW MEMBRANE PROTEIN 09/30/04 Pyochelin outer membrane receptor FptA from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA 2.0 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Lauryl Dimethylamine-N-Oxide DB04147 DrugBank 5.0.6 P42512 Fe(3+)-pyochelin receptor 100.0 720 0.0e+00

Virulence Evidence

Source 1
Database VFDB : VF0095
Category Pyochelin receptor
Host Organism

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 250 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001486 (1085 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: PA4221
Search term: fptA


FptA, the Fe(III)-pyochelin receptor of Pseudomonas aeruginosa: a phenolate siderophore receptor homologous to hydroxamate siderophore receptors.
Ankenbauer RG, Quan HN
J. Bacteriol. 1994 Jan;176(2):307-19
PubMed ID: 8288523
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res. 2005 Feb;15(2):321-9
PubMed ID: 15687295
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Proteomics of the oxidative stress response induced by hydrogen peroxide and paraquat reveals a novel AhpC-like protein in Pseudomonas aeruginosa.
Hare NJ, Scott NE, Shin EH, Connolly AM, Larsen MR, Palmisano G, Cordwell SJ
Proteomics 2011 Aug;11(15):3056-69
PubMed ID: 21674802