Pseudomonas aeruginosa PAO1, PA4589

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA4589
Name
Synonym: fadL
Replicon chromosome
Genomic location 5139050 - 5140441 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_253279.1
GI 15599785
Affymetrix PA4589_at
Entrez 881028
GenBank AAG07977.1
INSDC AAG07977.1
NCBI Locus Tag PA4589
protein_id(GenBank) gb|AAG07977.1|AE004872_8|gnl|PseudoCAP|PA4589
TIGR NTL03PA04590
UniParc UPI00000C5D79
UniProtKB Acc Q9HVJ6
UniProtKB ID Q9HVJ6_PSEAE
UniRef100 UniRef100_K1CEM0
UniRef50 UniRef50_E2XT92
UniRef90 UniRef90_B7V0D3

Product

Feature Type CDS
Coding Frame 1
Product Name
probable outer membrane protein precursor
Product Name Confidence: Class 3
Evidence for Translation
Charge (pH 7) -2.59
Kyte-Doolittle Hydrophobicity Value -0.247
Molecular Weight (kDa) 49.7
Isoelectric Point (pI) 6.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Outer Membrane Class 2
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3DWO MEMBRANE PROTEIN 07/22/08 Crystal structure of a Pseudomonas aeruginosa FadL homologue PSEUDOMONAS AERUGINOSA 2.2 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
(Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04233 DrugBank 5.0.6 Q9HVJ6 Probable outer membrane protein 100.0 463 1.3e-276

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 183 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004247 (362 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4589

Transposon Insertions in PAO1

Type ISphoA/hah insertion site
Mutant ID UWGC: 33400
Genomic Position 5140035
Position in ORF 986(1392)
Reference 14617778
Type ISlacZ/hah insertion site
Mutant ID UWGC: 7111
Genomic Position 5140134
Position in ORF 1085(1392)
Reference 14617778

Transposon Insertions in Orthologs

References

No references are associated with this feature.