Pseudomonas aeruginosa PAK, PAK_01337 (exoS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa PAK - Assembly GCF_000408865.1
GCF_000408865.1|latest
Locus Tag
PAK_01337
Name
exoS
Replicon chromosome
Genomic location 1424745 - 1426106 (+ strand)

Cross-References

RefSeq WP_016253040.1
GI 510932705
NCBI Locus Tag PAK_01337

Product

Feature Type CDS
Coding Frame 1
Product Name
exoenzyme S
Synonyms exoenzyme T
Evidence for Translation
Charge (pH 7) -6.81
Kyte-Doolittle Hydrophobicity Value -0.284
Molecular Weight (kDa) 48.2
Isoelectric Point (pI) 5.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1R4T TOXIN 10/08/03 Solution structure of exoenzyme S Pseudomonas aeruginosa NOT SOLUTION NMR 100.0
6GN8 TOXIN 05/30/18 Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form Homo sapiens; Pseudomonas aeruginosa 2.34 X-RAY DIFFRACTION 99.1
1HE1 SIGNALING PROTEIN 11/18/00 Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac HOMO SAPIENS; PSEUDOMONAS AERUGINOSA 2 X-RAY DIFFRACTION 100.0
6GN0 TOXIN 05/29/18 Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, tetrameric crystal form Homo sapiens; Pseudomonas aeruginosa 3.24 X-RAY DIFFRACTION 99.1
1HE9 TOXIN (EXOENZYME S) 11/21/00 Crystal structure of the GAP domain of the Pseudomonas aeruginosa ExoS toxin PSEUDOMONAS AERUGINOSA 2.4 X-RAY DIFFRACTION 100.0
4JMF TOXIN/CHAPERONE 03/14/13 Crystal structure of ExoT (residues 28 -77)- SpcS complex from Pseudomonas aeruginosa at 2.1 angstrom Pseudomonas aeruginosa 2.099 X-RAY DIFFRACTION 90.0
6GNK TOXIN 05/31/18 Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form bound to Carba-NAD Homo sapiens; Pseudomonas aeruginosa 2.55 X-RAY DIFFRACTION 99.1
6GNJ TOXIN 05/31/18 Exoenzyme S from Pseudomonas aeruginosa in complex with human 14-3-3 protein beta, trimeric crystal form in complex with STO1101 Homo sapiens; Pseudomonas aeruginosa 3.24 X-RAY DIFFRACTION 99.1

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG005145 (237 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PAK_01337
Search term: exoS
Search term: exoenzyme S

Human Homologs

References

No references are associated with this feature.