Pseudomonas aeruginosa PAO1, PA0437 (codA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0437
Name
codA
Replicon chromosome
Genomic location 489387 - 490658 (- strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_249128.1
GI 15595634
Affymetrix PA0437_codA_at
Entrez 877586
GenBank AAG03826.1
INSDC AAG03826.1
NCBI Locus Tag PA0437
protein_id(GenBank) gb|AAG03826.1|AE004481_2|gnl|PseudoCAP|PA0437
TIGR NTL03PA00438
UniParc UPI00000C5054
UniProtKB Acc Q9I680
UniProtKB ID Q9I680_PSEAE
UniRef100 UniRef100_W0YLR4
UniRef50 UniRef50_P25524
UniRef90 UniRef90_A6UYP8

Product

Feature Type CDS
Coding Frame 1
Product Name
cytosine deaminase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -9.19
Kyte-Doolittle Hydrophobicity Value -0.186
Molecular Weight (kDa) 47.1
Isoelectric Point (pI) 5.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000428 (493 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0437
Search term: codA

References

Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase.
Danielsen S, Kilstrup M, Barilla K, Jochimsen B, Neuhard J
Mol Microbiol 1992 May;6(10):1335-44
PubMed ID: 1640834
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994