Pseudomonas aeruginosa PAO1, PA1657 (hsiB2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1657
Name
hsiB2
Replicon chromosome
Genomic location 1805218 - 1805724 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250348.1
GI 15596854
Affymetrix PA1657_at
DNASU PaCD00006751
Entrez 879559
GenBank AAG05046.1
INSDC AAG05046.1
NCBI Locus Tag PA1657
protein_id(GenBank) gb|AAG05046.1|AE004593_8|gnl|PseudoCAP|PA1657
TIGR NTL03PA01658
UniParc UPI00000C542F
UniProtKB Acc Q9I368
UniProtKB ID Q9I368_PSEAE
UniRef100 UniRef100_W0YNN9
UniRef50 UniRef50_B6EJ78
UniRef90 UniRef90_W0YNN9

Product

Feature Type CDS
Coding Frame 1
Product Name
HsiB2
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.00
Kyte-Doolittle Hydrophobicity Value -0.330
Molecular Weight (kDa) 18.2
Isoelectric Point (pI) 4.54

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-2 encoded type VI secretion system (H2-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Homo sapiens
Notes H2-T6SS rendered inactive via clpV2 deletion.
Reference 22665491

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 108 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000082 (1224 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1657
Search term: hsiB2
Search term: HsiB2

Human Homologs

References

Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli.
Wang YD, Zhao S, Hill CW
J Bacteriol 1998 Aug;180(16):4102-10
PubMed ID: 9696756