Pseudomonas aeruginosa PAO1, PA2013 (liuC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA2013
Name
liuC
Synonym: gnyH
Synonym: menB
Replicon chromosome
Genomic location 2202649 - 2203446 (- strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250703.1
GI 15597209
Affymetrix PA2013_at
DNASU PaCD00006899
Entrez 879128
GenBank AAG05401.1
INSDC AAG05401.1
NCBI Locus Tag PA2013
protein_id(GenBank) gb|AAG05401.1|AE004627_9|gnl|PseudoCAP|PA2013
TIGR NTL03PA02013
UniParc UPI00000C5559
UniProtKB Acc Q9I298
UniProtKB ID Q9I298_PSEAE
UniRef100 UniRef100_W0YT12
UniRef50 UniRef50_Q4K9P5
UniRef90 UniRef90_A0A022P1B4

Product

Feature Type CDS
Coding Frame 1
Product Name
putative 3-methylglutaconyl-CoA hydratase
Product Name Confidence: Class 3
Synonyms gamma-carboxygeranoyl-CoA hydratase, GnyH
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.46
Kyte-Doolittle Hydrophobicity Value -0.033
Molecular Weight (kDa) 28.9
Isoelectric Point (pI) 5.19

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 492 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003426 (558 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2013
Search term: liuC

References

The gnyRDBHAL cluster is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa.
Díaz-Pérez AL, Zavala-Hernández AN, Cervantes C, Campos-García J
Appl. Environ. Microbiol. 2004 Sep;70(9):5102-10
PubMed ID: 15345388
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D
Appl. Environ. Microbiol. 2006 Jul;72(7):4819-28
PubMed ID: 16820476
A bacterial homolog to the mitochondrial enoyl-CoA hydratase.
Beckman DL, Kranz RG
Gene 1991 Oct;107(1):171-2
PubMed ID: 1743516
Menaquinone (vitamin K2) biosynthesis: nucleotide sequence and expression of the menB gene from Escherichia coli.
Sharma V, Suvarna K, Meganathan R, Hudspeth ME
J. Bacteriol. 1992 Aug;174(15):5057-62
PubMed ID: 1629162