Pseudomonas aeruginosa PAO1, PA2015 (liuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA2015
Name
liuA
Synonym: ivd
Synonym: gnyD
Replicon chromosome
Genomic location 2205190 - 2206353 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250705.1
GI 15597211
Affymetrix PA2015_at
DNASU PaCD00006900
Entrez 879167
GenBank AAG05403.1
INSDC AAG05403.1
NCBI Locus Tag PA2015
protein_id(GenBank) gb|AAG05403.1|AE004628_1|gnl|PseudoCAP|PA2015
TIGR NTL03PA02015
UniParc UPI00000C555B
UniProtKB Acc Q9I296
UniProtKB ID Q9I296_PSEAE
UniRef100 UniRef100_U8N0I4
UniRef50 UniRef50_Q92VK1
UniRef90 UniRef90_Q02LG2

Product

Feature Type CDS
Coding Frame 1
Product Name
putative isovaleryl-CoA dehydrogenase
Product Name Confidence: Class 2
Synonyms Citronelloyl-CoA dehydrogenase, GnyD
Ivd
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.67
Kyte-Doolittle Hydrophobicity Value -0.132
Molecular Weight (kDa) 42.2
Isoelectric Point (pI) 5.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 484 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003424 (559 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2015
Search term: liuA

Human Homologs

Ensembl 86, assembly GRCh38.p7
isovaleryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:6186]
E-value: 2.0e-136
Percent Identity: 64.0

References

The gnyRDBHAL cluster is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa.
Díaz-Pérez AL, Zavala-Hernández AN, Cervantes C, Campos-García J
Appl. Environ. Microbiol. 2004 Sep;70(9):5102-10
PubMed ID: 15345388
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D
Appl. Environ. Microbiol. 2006 Jul;72(7):4819-28
PubMed ID: 16820476
Isolation of cDNA clones coding for rat isovaleryl-CoA dehydrogenase and assignment of the gene to human chromosome 15.
Kraus JP, Matsubara Y, Barton D, Yang-Feng TL, Glassberg R, Ito M, Ikeda Y, Mole J, Francke U, Tanaka K
Genomics 1987 Nov;1(3):264-9
PubMed ID: 3446585