Pseudomonas aeruginosa PAO1, PA2016 (liuR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2016
Name
liuR
Synonym: gnyR
Replicon chromosome
Genomic location 2206402 - 2206806 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250706.1
GI 15597212
Affymetrix PA2016_at
DNASU PaCD00006901
Entrez 878723
GenBank AAG05404.1
INSDC AAG05404.1
NCBI Locus Tag PA2016
protein_id(GenBank) gb|AAG05404.1|AE004628_2|gnl|PseudoCAP|PA2016
TIGR NTL03PA02016
UniParc UPI00000C555C
UniProtKB Acc Q9I295
UniProtKB ID Q9I295_PSEAE
UniRef100 UniRef100_W0YPW1
UniRef50 UniRef50_B7VA89
UniRef90 UniRef90_B7VA89

Product

Feature Type CDS
Coding Frame 1
Product Name
regulator of liu genes
Product Name Confidence: Class 1
Synonyms Regulatory gene of gnyRDBHAL cluster, GnyR
GnyR
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.82
Kyte-Doolittle Hydrophobicity Value -0.647
Molecular Weight (kDa) 15.6
Isoelectric Point (pI) 5.37

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 312 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003423 (524 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2016
Search term: liuR

Human Homologs

References

The gnyRDBHAL cluster is involved in acyclic isoprenoid degradation in Pseudomonas aeruginosa.
Díaz-Pérez AL, Zavala-Hernández AN, Cervantes C, Campos-García J
Appl Environ Microbiol 2004 Sep;70(9):5102-10
PubMed ID: 15345388
Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa.
Förster-Fromme K, Höschle B, Mack C, Bott M, Armbruster W, Jendrossek D
Appl Environ Microbiol 2006 Jul;72(7):4819-28
PubMed ID: 16820476