Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA2020
|
Name |
mexZ
Synonym: mexZ Synonym: amrR |
Replicon | chromosome |
Genomic location | 2212677 - 2213309 (+ strand) |
Transposon Mutants | 2 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 1 transposon mutants in orthologs |
RefSeq | NP_250710.1 |
GI | 15597216 |
Affymetrix | PA2020_at |
Entrez | 880025 |
GenBank | AAG05408.1 |
INSDC | AAG05408.1 |
NCBI Locus Tag | PA2020 |
protein_id(GenBank) | gb|AAG05408.1|AE004628_6|gnl|PseudoCAP|PA2020 |
TIGR | NTL03PA02020 |
UniParc | UPI00000D421F |
UniProtKB Acc | G3XCU9 |
UniProtKB ID | G3XCU9_PSEAE |
UniRef100 | UniRef100_W0YRR0 |
UniRef50 | UniRef50_Q2SVT2 |
UniRef90 | UniRef90_W0YRR0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
MexZ
|
Synonyms | |
Evidence for Translation | |
Charge (pH 7) | 0.06 |
Kyte-Doolittle Hydrophobicity Value | -0.350 |
Molecular Weight (kDa) | 23.7 |
Isoelectric Point (pI) | 7.06 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexZ | MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. [PMID:15336398] | ARO:3003709 | protein overexpression model | Strict | 420.2 | 100.0 | 3.2.5 |
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
2WUI | TRANSCRIPTION | 10/05/09 | Crystal Structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa. | PSEUDOMONAS AERUGINOSA | 2.9 | X-RAY DIFFRACTION | 100.0 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 249 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG003420 (237 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA2020
Search term: mexZ
Search term: MexZ
|
MexZ-mediated regulation of mexXY multidrug efflux pump expression in Pseudomonas aeruginosa by binding on the mexZ-mexX intergenic DNA.
Matsuo Y, Eda S, Gotoh N, Yoshihara E, Nakae T
FEMS Microbiol Lett 2004 Sep 1;238(1):23-8
PubMed ID: 15336398
|
Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fibrosis results from convergent evolution in the mexZ gene.
Prickett MH, Hauser AR, McColley SA, Cullina J, Potter E, Powers C, Jain M
Thorax 2017 Jan;72(1):40-47
PubMed ID: 27325751
|