Pseudomonas aeruginosa PAO1, PA2320 (gntR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2320
Name
gntR
Synonym: gnuR
Replicon chromosome
Genomic location 2558918 - 2559949 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251010.1
GI 15597516
Affymetrix PA2320_gntR_at
Entrez 883124
GenBank AAG05708.1
INSDC AAG05708.1
NCBI Locus Tag PA2320
protein_id(GenBank) gb|AAG05708.1|AE004658_2|gnl|PseudoCAP|PA2320
TIGR NTL03PA02320
UniParc UPI00000C5668
UniProtKB Acc Q9I1F6
UniProtKB ID Q9I1F6_PSEAE
UniRef100 UniRef100_W0YQU5
UniRef50 UniRef50_Q4K7W8
UniRef90 UniRef90_A6V5G5

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator GntR
Product Name Confidence: Class 1
Synonyms gluconate repressor
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.82
Kyte-Doolittle Hydrophobicity Value -0.083
Molecular Weight (kDa) 37.1
Isoelectric Point (pI) 8.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 370 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003187 (512 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2320
Search term: gntR

Human Homologs

References

Cloning and molecular genetic characterization of the Escherichia coli gntR, gntK, and gntU genes of GntI, the main system for gluconate metabolism.
Tong S, Porco A, Isturiz T, Conway T
J Bacteriol 1996 Jun;178(11):3260-9
PubMed ID: 8655507
Gene organization and transcriptional regulation of the gntRKU operon involved in gluconate uptake and catabolism of Escherichia coli.
Izu H, Adachi O, Yamada M
J Mol Biol 1997 Apr 11;267(4):778-93
PubMed ID: 9135111
Identification of GntR as regulator of the glucose metabolism in Pseudomonas aeruginosa.
Daddaoua A, Corral-Lugo A, Ramos JL, Krell T
Environ Microbiol 2017 Sep;19(9):3721-3733
PubMed ID: 28752954