Pseudomonas aeruginosa PAO1, PA2373 (vgrG3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA2373
Name
vgrG3
Replicon chromosome
Genomic location 2624204 - 2626210 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 10 transposon mutants in orthologs

Cross-References

RefSeq NP_251063.1
GI 15597569
Affymetrix PA2373_at
Entrez 878107
GenBank AAG05761.1
INSDC AAG05761.1
NCBI Locus Tag PA2373
protein_id(GenBank) gb|AAG05761.1|AE004663_7|gnl|PseudoCAP|PA2373
TIGR NTL03PA02373
UniParc UPI00000C5699
UniProtKB Acc Q9I1A6
UniProtKB ID Q9I1A6_PSEAE
UniRef100 UniRef100_Q9I1A6
UniRef50 UniRef50_D2TPV2
UniRef90 UniRef90_Q9I1A6

Product

Feature Type CDS
Coding Frame 1
Product Name
VgrG3
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -15.49
Kyte-Doolittle Hydrophobicity Value -0.391
Molecular Weight (kDa) 71.9
Isoelectric Point (pI) 5.16

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000317
genomic context evidence used in manual assertion
Host Organism Caenorhabditis elegans
Notes
Infection model Caenorhabditis elegans slow killing assay. H3-T6SS rendered inactive via clpV3 deletion.
Reference 24204589

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 171 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000090 (3404 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2373
Search term: vgrG3
Search term: VgrG3

References

Rhs elements comprise three subfamilies which diverged prior to acquisition by Escherichia coli.
Wang YD, Zhao S, Hill CW
J. Bacteriol. 1998 Aug;180(16):4102-10
PubMed ID: 9696756
Type VI secretion system in Pseudomonas aeruginosa: secretion and multimerization of VgrG proteins.
Hachani A, Lossi NS, Hamilton A, Jones C, Bleves S, Albesa-Jové D, Filloux A
J. Biol. Chem. 2011 Apr;286(14):12317-27
PubMed ID: 21325275
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.
Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ
Science 2006 Jun;312(5779):1526-30
PubMed ID: 16763151
Divergent control of two type VI secretion systems by RpoN in Pseudomonas aeruginosa.
Sana TG, Soscia C, Tonglet CM, Garvis S, Bleves S
PLoS ONE 2013 ;8(10):e76030
PubMed ID: 24204589