Pseudomonas aeruginosa PAO1, PA2947 (cobE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
Locus Tag
PA2947
Name
cobE
Synonym: cbiG
Replicon chromosome
Genomic location 3307085 - 3307513 (+ strand)

Cross-References

RefSeq NP_251637.1
GI 15598143
Affymetrix PA2947_i_at
DNASU PaCD00007284
Entrez 882836
GenBank AAG06335.1
INSDC AAG06335.1
NCBI Locus Tag PA2947
protein_id(GenBank) gb|AAG06335.1|AE004721_3|gnl|PseudoCAP|PA2947
TIGR NTL03PA02947
UniParc UPI00000C589E
UniProtKB Acc Q9HZQ0
UniProtKB ID Q9HZQ0_PSEAE
UniRef100 UniRef100_W0YUA1
UniRef50 UniRef50_A0A022P7E3
UniRef90 UniRef90_A0A022P7E3

Product

Feature Type CDS
Coding Frame 1
Product Name
CobE
Product Name Confidence: Class 1
Evidence for Translation
Charge (pH 7) -0.14
Kyte-Doolittle Hydrophobicity Value 0.025
Molecular Weight (kDa) 15.1
Isoelectric Point (pI) 6.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2W6K BIOSYNTHETIC PROTEIN 12/18/08 The crystal structure at 1.7 A resolution of CobE, a protein from the cobalamin (vitamin B12) biosynthetic pathway PSEUDOMONAS AERUGINOSA 1.7 X-RAY DIFFRACTION 100.0
2W6L BIOSYNTHETIC PROTEIN 12/18/08 The crystal structure at 1.7 A resolution of CobE, a protein from the cobalamin (vitamin B12) biosynthetic pathway PSEUDOMONAS AERUGINOSA 1.89 X-RAY DIFFRACTION 99.3

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 133 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002633 (419 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2947
Search term: cobE
Search term: CobE

References

Crystallization and preliminary structure analysis of CobE, an essential protein of cobalamin (vitamin B12) biosynthesis.
Vévodová J, Graham RM, Raux E, Warren MJ, Wilson KS
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005 Apr;61(Pt 4):442-4
PubMed ID: 16511064