Pseudomonas aeruginosa PAO1, PA2947 (cobE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2947
Name
cobE
Synonym: cbiG
Replicon chromosome
Genomic location 3307085 - 3307513 (+ strand)

Cross-References

RefSeq NP_251637.1
GI 15598143
Affymetrix PA2947_i_at
DNASU PaCD00007284
Entrez 882836
GenBank AAG06335.1
INSDC AAG06335.1
NCBI Locus Tag PA2947
protein_id(GenBank) gb|AAG06335.1|AE004721_3|gnl|PseudoCAP|PA2947
TIGR NTL03PA02947
UniParc UPI00000C589E
UniProtKB Acc Q9HZQ0
UniProtKB ID Q9HZQ0_PSEAE
UniRef100 UniRef100_W0YUA1
UniRef50 UniRef50_A0A022P7E3
UniRef90 UniRef90_A0A022P7E3

Product

Feature Type CDS
Coding Frame 1
Product Name
CobE
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -0.14
Kyte-Doolittle Hydrophobicity Value 0.025
Molecular Weight (kDa) 15.1
Isoelectric Point (pI) 6.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2W6L BIOSYNTHETIC PROTEIN 12/18/08 The crystal structure at 1.7 A resolution of CobE, a protein from the cobalamin (vitamin B12) biosynthetic pathway PSEUDOMONAS AERUGINOSA 1.89 X-RAY DIFFRACTION 99.3
2W6K BIOSYNTHETIC PROTEIN 12/18/08 The crystal structure at 1.7 A resolution of CobE, a protein from the cobalamin (vitamin B12) biosynthetic pathway PSEUDOMONAS AERUGINOSA 1.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 133 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002633 (409 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2947
Search term: cobE
Search term: CobE

Human Homologs

References

Crystallization and preliminary structure analysis of CobE, an essential protein of cobalamin (vitamin B12) biosynthesis.
Vévodová J, Graham RM, Raux E, Warren MJ, Wilson KS
Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Apr 1;61(Pt 4):442-4
PubMed ID: 16511064