Pseudomonas aeruginosa PAO1, PA3183 (zwf)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA3183
Name
zwf
Replicon chromosome
Genomic location 3572324 - 3573793 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_251873.1
GI 15598379
Affymetrix PA3183_zwf_at
Entrez 882681
GenBank AAG06571.1
INSDC AAG06571.1
NCBI Locus Tag PA3183
protein_id(GenBank) gb|AAG06571.1|AE004742_7|gnl|PseudoCAP|PA3183
TIGR NTL03PA03183
UniParc UPI000012AF2D
UniProtKB Acc O68282
UniProtKB ID G6PD_PSEAE
UniRef100 UniRef100_O68282
UniRef50 UniRef50_O68282
UniRef90 UniRef90_O68282

Product

Feature Type CDS
Coding Frame 1
Product Name
glucose-6-phosphate 1-dehydrogenase
Product Name Confidence: Class 1
Synonyms G6PD
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -8.45
Kyte-Doolittle Hydrophobicity Value -0.262
Molecular Weight (kDa) 55.6
Isoelectric Point (pI) 5.68

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 391 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002433 (547 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3183
Search term: zwf

Human Homologs

Ensembl 97, assembly GRCh38.p12
glucose-6-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4057]
E-value: 7.9e-83
Percent Identity: 36.1

Human Homologs

Ensembl 97, assembly GRCh38.p12
glucose-6-phosphate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4057]
E-value: 7.9e-83
Percent Identity: 36.1

References

Cloning and characterization of the Pseudomonas aeruginosa zwf gene encoding glucose-6-phosphate dehydrogenase, an enzyme important in resistance to methyl viologen (paraquat).
Ma JF, Hager PW, Howell ML, Phibbs PV, Hassett DJ
J. Bacteriol. 1998 Apr;180(7):1741-9
PubMed ID: 9537370