Pseudomonas aeruginosa UCBPP-PA14, PA14_34030 (hcp3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_34030
Name
hcp3
Replicon chromosome
Genomic location 3027086 - 3027583 (- strand)
Transposon Mutants in orthologs 4 transposon mutants in orthologs
CommentHcp Secretion Island-III-encoded type VI secretion system (H3-T6SS)

Cross-References

RefSeq YP_790876.1
GI 116050307
Entrez 4385126
INSDC ABJ11543.1
NCBI Locus Tag PA14_34030
UniParc UPI00000C5693
UniProtKB Acc Q02MG0
UniProtKB ID Q02MG0_PSEAB
UniRef100 UniRef100_W0YU48
UniRef50 UniRef50_D2TPU7
UniRef90 UniRef90_W0YU48

Product

Feature Type CDS
Coding Frame 1
Product Name
Hcp3
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -5.59
Kyte-Doolittle Hydrophobicity Value -0.142
Molecular Weight (kDa) 17.6
Isoelectric Point (pI) 4.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 19497948

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 70 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000084 (777 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_34030
Search term: hcp3
Search term: Hcp3

References

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading, Engl.) 2009 Sep;155(Pt 9):2845-55
PubMed ID: 19497948
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A.
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7707-7712.
PubMed ID: 28673999
Crystal structure of secretory protein Hcp3 from Pseudomonas aeruginosa.
Osipiuk J, Xu X, Cui H, Savchenko A, Edwards A, Joachimiak A.
J Struct Funct Genomics. 2011 Mar;12(1):21-6.
PubMed ID: 21476004