Pseudomonas aeruginosa UCBPP-PA14, PA14_34140 (hsiA3)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_34140
Name
hsiA3
Synonym: tssA3
Replicon chromosome
Genomic location 3036369 - 3037469 (+ strand)
Transposon Mutants in orthologs 7 transposon mutants in orthologs
CommentHcp Secretion Island-III-encoded type VI secretion system (H3-T6SS)

Cross-References

RefSeq YP_790883.1
GI 116050300
Entrez 4385119
INSDC ABJ11536.1
NCBI Locus Tag PA14_34140
UniParc UPI0000396AB7
UniProtKB Acc Q02MF3
UniProtKB ID Q02MF3_PSEAB
UniRef100 UniRef100_Q02MF3
UniRef50 UniRef50_W0YSA6
UniRef90 UniRef90_W0YSA6

Product

Feature Type CDS
Coding Frame 1
Product Name
HsiA3
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -14.20
Kyte-Doolittle Hydrophobicity Value -0.370
Molecular Weight (kDa) 40.8
Isoelectric Point (pI) 4.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database PseudoCAP
Category Hcp secretion island-3 encoded type VI secretion system (H3-T6SS)
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration model
Reference 19497948

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 79 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000081 (1226 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_34140
Search term: hsiA3
Search term: HsiA3

References

Quorum sensing differentially regulates Pseudomonas aeruginosa type VI secretion locus I and homologous loci II and III, which are required for pathogenesis.
Lesic B, Starkey M, He J, Hazan R, Rahme LG
Microbiology (Reading, Engl.) 2009 Sep;155(Pt 9):2845-55
PubMed ID: 19497948
RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A.
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7707-7712.
PubMed ID: 28673999