Pseudomonas aeruginosa UCBPP-PA14, PA14_67180 (tli5b4)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_67180
Name
tli5b4
Replicon chromosome
Genomic location 5995985 - 5996854 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_793555.1
GI 116053232
Entrez 4383397
NCBI Locus Tag PA14_67180

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion lipase immunity protein, Tli5b4
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 1.34
Kyte-Doolittle Hydrophobicity Value -0.354
Molecular Weight (kDa) 32278.6
Isoelectric Point (pI) 7.57

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5JKP IMMUNE SYSTEM 04/26/16 Crystal structure of immunity protein Pa5087 from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 2.106 X-RAY DIFFRACTION 90.3
6LCH PROTEIN BINDING 11/19/19 Pseudomonas aeruginosa 5086 (PA5086) Pseudomonas aeruginosa 1.899 X-RAY DIFFRACTION 96.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 91 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG015014 (76 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_67180
Search term: tli5b4

Human Homologs

References

RsmA and AmrZ orchestrate the assembly of all three type VI secretion systems in Pseudomonas aeruginosa.
Allsopp LP, Wood TE, Howard SA, Maggiorelli F, Nolan LM, Wettstadt S, Filloux A
Proc Natl Acad Sci U S A 2017 Jul 18;114(29):7707-7712
PubMed ID: 28673999