Pseudomonas stutzeri A1501, PST_0399

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse

Gene Feature Overview

Strain Pseudomonas stutzeri A1501
Locus Tag
PST_0399
Name
Synonym: D2HGDH
Replicon chromosome
Genomic location 452104 - 453498 (+ strand)

Cross-References

RefSeq YP_001170947.1
GI 146280794
Entrez 5094894
INSDC ABP78105.1
NCBI Locus Tag PST_0399
UniParc UPI00014FE8CA
UniProtKB Acc A4VGK4
UniProtKB ID A4VGK4_PSEU5
UniRef100 UniRef100_A4VGK4
UniRef50 UniRef50_A0A077SBA9
UniRef90 UniRef90_A4VGK4

Product

Feature Type CDS
Coding Frame 1
Product Name
D-2-hydroxyglutarate dehydrogenase
Product Name Confidence: Class 1
Synonyms oxidoreductase, FAD-binding
Evidence for Translation
Charge (pH 7) -17.94
Kyte-Doolittle Hydrophobicity Value -0.101
Molecular Weight (kDa) 51.1
Isoelectric Point (pI) 4.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 547 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000314 (553 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PST_0399

Human Homologs

Ensembl 86, assembly GRCh38.p7
D-2-hydroxyglutarate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:28358]
E-value: 9.0e-75
Percent Identity: 35.3

References

Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.
Zhang W, Zhang M, Gao C, Zhang Y, Ge Y, Guo S, Guo X, Zhou Z, Liu Q, Zhang Y, Ma C, Tao F, Xu P.
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7574-E7582.
PubMed ID: 28827360