Pseudomonas stutzeri A1501, PST_0399
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain | Pseudomonas stutzeri A1501 |
| Locus Tag |
PST_0399
|
| Name |
Synonym: D2HGDH |
| Replicon | chromosome |
| Genomic location | 452104 - 453498 (+ strand) |
Cross-References
| RefSeq | YP_001170947.1 |
| GI | 146280794 |
| Entrez | 5094894 |
| INSDC | ABP78105.1 |
| NCBI Locus Tag | PST_0399 |
| UniParc | UPI00014FE8CA |
| UniProtKB Acc | A4VGK4 |
| UniProtKB ID | A4VGK4_PSEU5 |
| UniRef100 | UniRef100_A4VGK4 |
| UniRef50 | UniRef50_A0A077SBA9 |
| UniRef90 | UniRef90_A4VGK4 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
D-2-hydroxyglutarate dehydrogenase
|
| Evidence for Translation | |
| Charge (pH 7) | -17.94 |
| Kyte-Doolittle Hydrophobicity Value | -0.101 |
| Molecular Weight (kDa) | 51.1 |
| Isoelectric Point (pI) | 4.67 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 547 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000314 (553 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PST_0399
Search term: D-2-hydroxyglutarate dehydrogenase
|
Human Homologs
|
Ensembl
86, assembly
GRCh38.p7
|
D-2-hydroxyglutarate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:28358]
E-value:
9.0e-75
Percent Identity:
35.3
|
References
|
Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.
Zhang W, Zhang M, Gao C, Zhang Y, Ge Y, Guo S, Guo X, Zhou Z, Liu Q, Zhang Y, Ma C, Tao F, Xu P.
Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7574-E7582.
PubMed ID: 28827360
|