Pseudomonas putida KT2440, PP_2674 (pedE)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas putida KT2440 (TIGR)
GCF_000007565.2|latest |
| Locus Tag |
PP_2674
|
| Name |
pedE
Synonym: qedH-I |
| Replicon | chromosome |
| Genomic location | 3061566 - 3063461 (- strand) |
| Comment | The lanthanum-dependent transcriptional repression through PedR2 is influenced by the environmental concentration of iron |
| Comment | Transcriptionally repressed in the presence of lanthanides |
| Comment | |
| Comment | New function/Role: Initiates an alternative route for glycerol metabolism that provides a growth advantage by reducing the lag phase of the cells |
Cross-References
| RefSeq | NP_744818.1 |
| GI | 26989393 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
PedE
|
| Synonyms |
quinoprotein ethanol dehydrogenase |
| Evidence for Translation | |
| Charge (pH 7) | |
| Kyte-Doolittle Hydrophobicity Value | -0.473 |
| Molecular Weight (kDa) | 69.2 |
| Isoelectric Point (pI) | 6.52 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results | Analysis not done |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group | |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PP_2674
Search term: pedE
Search term: PedE
|
Human Homologs
References
|
Functional Role of Lanthanides in Enzymatic Activity and Transcriptional Regulation of Pyrroloquinoline Quinone-Dependent Alcohol Dehydrogenases in Pseudomonas putida KT2440.
Wehrmann M, Billard P, Martin-Meriadec A, Zegeye A, Klebensberger J
mBio 2017 Jun 27;8(3)
PubMed ID: 28655819
|
|
The PedS2/PedR2 Two-Component System Is Crucial for the Rare Earth Element Switch in Pseudomonas putida KT2440.
Wehrmann M, Berthelot C, Billard P, Klebensberger J
mSphere 2018 Aug 29;3(4)
PubMed ID: 30158283
|
|
The Cellular Response to Lanthanum Is Substrate Specific and Reveals a Novel Route for Glycerol Metabolism in Pseudomonas putida KT2440.
Wehrmann M, Toussaint M, Pfannstiel J, Billard P, Klebensberger J
mBio 2020 Apr 28;11(2)
PubMed ID: 32345644
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Rare Earth Element (REE)-Dependent Growth of Pseudomonas putida KT2440 Relies on the ABC-Transporter PedA1A2BC and Is Influenced by Iron Availability.
Wehrmann M, Berthelot C, Billard P, Klebensberger J
Front Microbiol 2019;10:2494
PubMed ID: 31736923
|