Strain |
Pseudomonas putida KT2440 (TIGR)
GCF_000007565.2|latest |
Locus Tag |
PP_2679
|
Name |
pedH
Synonym: qedH-II |
Replicon | chromosome |
Genomic location | 3066962 - 3068749 (+ strand) |
Comment | Protein is involved in the lanthanide-dependent signaling leading to transcriptional autoactivation |
Comment | New function/Role: Initiates an alternative route for glycerol metabolism that provides a growth advantage by reducing the lag phase of the cells |
Comment | PedH-dependent growth with 2-phenylethanol under low (nM) concentrations of lanthanides relies on the ABC transporter PedA1A2BC |
RefSeq | NP_744823.1 |
GI | 26989398 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
PedH
|
Synonyms |
quinoprotein ethanol dehydrogenase |
Evidence for Translation | |
Charge (pH 7) | |
Kyte-Doolittle Hydrophobicity Value | -0.293 |
Molecular Weight (kDa) | 64.9 |
Isoelectric Point (pI) | 8.75 |
Individual Mappings | |
Additional evidence for subcellular localization |
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
6ZCW | OXIDOREDUCTASE | 06/12/20 | Crystal structure of lanthanide-dependent alcohol dehydrogenase PedH from Pseudomonas putida KT2440 | Pseudomonas putida KT2440 | 1.65 | X-RAY DIFFRACTION | 99.8 |
6ZCV | OXIDOREDUCTASE | 06/12/20 | Crystal structure of lanthanide-dependent alcohol dehydrogenase PedH from Pseudomonas putida KT2440 | Pseudomonas putida KT2440 | 1.7 | X-RAY DIFFRACTION | 99.7 |
Results | Analysis not done |
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group | |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PP_2679
Search term: pedH
Search term: PedH
|
Functional Role of Lanthanides in Enzymatic Activity and Transcriptional Regulation of Pyrroloquinoline Quinone-Dependent Alcohol Dehydrogenases in Pseudomonas putida KT2440.
Wehrmann M, Billard P, Martin-Meriadec A, Zegeye A, Klebensberger J
mBio 2017 Jun 27;8(3)
PubMed ID: 28655819
|
The Cellular Response to Lanthanum Is Substrate Specific and Reveals a Novel Route for Glycerol Metabolism in Pseudomonas putida KT2440.
Wehrmann M, Toussaint M, Pfannstiel J, Billard P, Klebensberger J
mBio 2020 Apr 28;11(2)
PubMed ID: 32345644
|
Rare Earth Element (REE)-Dependent Growth of Pseudomonas putida KT2440 Relies on the ABC-Transporter PedA1A2BC and Is Influenced by Iron Availability.
Wehrmann M, Berthelot C, Billard P, Klebensberger J
Front Microbiol 2019;10:2494
PubMed ID: 31736923
|