Pseudomonas aeruginosa PAO1, PA0865 (hpd)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse View in GBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Reference)
GCF_000006765.1|latest
Locus Tag
PA0865
Name
hpd
Replicon chromosome
Genomic location 945834 - 946907 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_249556.1
GI 15596062
Affymetrix PA0865_hpd_at
Entrez 882225
GenBank AAG04254.1
INSDC AAG04254.1
NCBI Locus Tag PA0865
protein_id(GenBank) gb|AAG04254.1|AE004521_5|gnl|PseudoCAP|PA0865
TIGR NTL03PA00866
UniParc UPI00000C5197
UniProtKB Acc Q9I576
UniProtKB ID HPPD_PSEAE
UniRef100 UniRef100_Q9I576
UniRef50 UniRef50_Q9I576
UniRef90 UniRef90_Q9I576

Product

Feature Type CDS
Coding Frame 1
Product Name
4-hydroxyphenylpyruvate dioxygenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -14.40
Kyte-Doolittle Hydrophobicity Value -0.313
Molecular Weight (kDa) 39.9
Isoelectric Point (pI) 4.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 222 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000832 (548 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA0865
Search term: hpd

Human Homologs

Ensembl 97, assembly GRCh38.p12
4-hydroxyphenylpyruvate dioxygenase like [Source:HGNC Symbol;Acc:HGNC:28242]
E-value: 6.1e-16
Percent Identity: 36.4

References

Characterization of 4-hydroxyphenylpyruvate dioxygenase. Primary structure of the Pseudomonas enzyme.
Rüetschi U, Odelhög B, Lindstedt S, Barros-Söderling J, Persson B, Jörnvall H
Eur J Biochem 1992 Apr 15;205(2):459-66
PubMed ID: 1572351
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994