Pseudomonas aeruginosa PAO1, PA1375 (pdxB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1375
Name
pdxB
Replicon chromosome
Genomic location 1491913 - 1493055 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250066.1
GI 15596572
Affymetrix PA1375_pdxB_at
Entrez 881132
GenBank AAG04764.1
INSDC AAG04764.1
NCBI Locus Tag PA1375
protein_id(GenBank) gb|AAG04764.1|AE004567_3|gnl|PseudoCAP|PA1375
TIGR NTL03PA01376
UniParc UPI00000C5345
UniProtKB Acc Q9I3W9
UniProtKB ID PDXB_PSEAE
UniRef100 UniRef100_Q9I3W9
UniRef50 UniRef50_Q9I3W9
UniRef90 UniRef90_Q9I3W9

Product

Feature Type CDS
Coding Frame 1
Product Name
erythronate-4-phosphate dehydrogenase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.79
Kyte-Doolittle Hydrophobicity Value -0.016
Molecular Weight (kDa) 41.0
Isoelectric Point (pI) 5.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2O4C OXIDOREDUCTASE 12/04/06 Crystal Structure of D-Erythronate-4-phosphate Dehydrogenase Complexed with NAD Pseudomonas aeruginosa 2.3 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 633 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001304 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1375
Search term: pdxB

Human Homologs

References

Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette.
Arps PJ, Winkler ME
J Bacteriol 1987 Mar;169(3):1061-70
PubMed ID: 3029016
Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12.
Schoenlein PV, Roa BB, Winkler ME
J Bacteriol 1989 Nov;171(11):6084-92
PubMed ID: 2681152