Pseudomonas aeruginosa PAO1, PA1376 (aceK)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1376
Name
aceK
Replicon chromosome
Genomic location 1493090 - 1494823 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250067.1
GI 15596573
Affymetrix PA1376_aceK_at
Entrez 881156
GenBank AAG04765.1
INSDC AAG04765.1
NCBI Locus Tag PA1376
protein_id(GenBank) gb|AAG04765.1|AE004567_4|gnl|PseudoCAP|PA1376
TIGR NTL03PA01377
UniParc UPI00000C5346
UniProtKB Acc Q9I3W8
UniProtKB ID ACEK_PSEAE
UniRef100 UniRef100_Q9I3W8
UniRef50 UniRef50_A4VMC4
UniRef90 UniRef90_Q9I3W8

Product

Feature Type CDS
Coding Frame 1
Product Name
isocitrate dehydrogenase kinase/phosphatase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -17.99
Kyte-Doolittle Hydrophobicity Value -0.301
Molecular Weight (kDa) 66.8
Isoelectric Point (pI) 4.98

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 74 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001305 (495 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1376
Search term: aceK

Human Homologs

References

Nucleotide sequence and expression of the aceK gene coding for isocitrate dehydrogenase kinase/phosphatase in Escherichia coli.
Cortay JC, Bleicher F, Rieul C, Reeves HC, Cozzone AJ
J Bacteriol 1988 Jan;170(1):89-97
PubMed ID: 2826408