Pseudomonas aeruginosa PAO1, PA1393 (cysC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1393
Name
cysC
Replicon chromosome
Genomic location 1515337 - 1515927 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_250084.1
GI 15596590
Affymetrix PA1393_cysC_at
Entrez 877968
GenBank AAG04782.1
INSDC AAG04782.1
NCBI Locus Tag PA1393
protein_id(GenBank) gb|AAG04782.1|AE004568_11|gnl|PseudoCAP|PA1393
TIGR NTL03PA01394
UniParc UPI0000128B41
UniProtKB Acc P57702
UniProtKB ID CYSC_PSEAE
UniRef100 UniRef100_P57702
UniRef50 UniRef50_Q87SX6
UniRef90 UniRef90_P57702

Product

Feature Type CDS
Coding Frame 1
Product Name
adenosine 5'-phosphosulfate (APS) kinase
Product Name Confidence: Class 2
Synonyms adenylylsulfate kinase
ATP:APS 3'-phosphotransferase
Evidence for Translation
Charge (pH 7) -0.34
Kyte-Doolittle Hydrophobicity Value -0.383
Molecular Weight (kDa) 22.1
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 362 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001314 (225 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1393
Search term: cysC

Human Homologs

Ensembl 110, assembly GRCh38.p14
3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Source:HGNC Symbol;Acc:HGNC:8603]
E-value: 2.7e-41
Percent Identity: 50.3

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The sulfate activation locus of Escherichia coli K12: cloning, genetic, and enzymatic characterization.
Leyh TS, Taylor JC, Markham GD
J Biol Chem 1988 Feb 15;263(5):2409-16
PubMed ID: 2828368
The DNA sequence of the sulfate activation locus from Escherichia coli K-12.
Leyh TS, Vogt TF, Suo Y
J Biol Chem 1992 May 25;267(15):10405-10
PubMed ID: 1316900