Pseudomonas aeruginosa PAO1, PA1461 (motD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1461
Name
motD
Synonym: motB
Replicon chromosome
Genomic location 1591286 - 1592176 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentMotC-MotD require MotY for optimal function. MotCD and MotY are necessary for movement in viscous environments and over surfaces.

Cross-References

RefSeq NP_250152.1
GI 15596658
Affymetrix PA1461_at
Entrez 880913
GenBank AAG04850.1
INSDC AAG04850.1
NCBI Locus Tag PA1461
protein_id(GenBank) gb|AAG04850.1|AE004575_9|gnl|PseudoCAP|PA1461
TIGR NTL03PA01462
UniParc UPI00000D4289
UniProtKB Acc G3XD90
UniProtKB ID G3XD90_PSEAE
UniRef100 UniRef100_W0YPQ1
UniRef50 UniRef50_Q88EW7
UniRef90 UniRef90_B7UW90

Product

Feature Type CDS
Coding Frame 1
Product Name
MotD
Product Name Confidence: Class 3
Synonyms MotB
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -6.55
Kyte-Doolittle Hydrophobicity Value -0.394
Molecular Weight (kDa) 32.1
Isoelectric Point (pI) 5.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0273
Category Flagella
Evidence
Host Organism
Notes
Reference 14617143

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 418 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001376 (532 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1461
Search term: motD
Search term: MotD

Human Homologs

References

The complex flagellar torque generator of Pseudomonas aeruginosa.
Doyle TB, Hawkins AC, McCarter LL
J Bacteriol 2004 Oct;186(19):6341-50
PubMed ID: 15375113
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295