Pseudomonas aeruginosa PAO1, PA1544 (anr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1544
Name
anr
Replicon chromosome
Genomic location 1681071 - 1681805 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250235.1
GI 15596741
Affymetrix PA1544_anr_at
Entrez 883009
GenBank AAG04933.1
INSDC AAG04933.1
NCBI Locus Tag PA1544
protein_id(GenBank) gb|AAG04933.1|AE004582_11|gnl|PseudoCAP|PA1544
TIGR NTL03PA01545
UniParc UPI0000125B57
UniProtKB Acc P23926
UniProtKB ID ANR_PSEAE
UniRef100 UniRef100_P23926
UniRef50 UniRef50_P23926
UniRef90 UniRef90_P23926

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator Anr
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.42
Kyte-Doolittle Hydrophobicity Value -0.119
Molecular Weight (kDa) 27.1
Isoelectric Point (pI) 5.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 455 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003816 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1544
Search term: anr

Human Homologs

References

The ArgR regulatory protein, a helper to the anaerobic regulator ANR during transcriptional activation of the arcD promoter in Pseudomonas aeruginosa.
Lu CD, Winteler H, Abdelal A, Haas D
J Bacteriol 1999 Apr;181(8):2459-64
PubMed ID: 10198009
Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on anr, a regulatory gene homologous with fnr of Escherichia coli.
Zimmermann A, Reimmann C, Galimand M, Haas D
Mol Microbiol 1991 Jun;5(6):1483-90
PubMed ID: 1787798
The homologous regulators ANR of Pseudomonas aeruginosa and FNR of Escherichia coli have overlapping but distinct specificities for anaerobically inducible promoters.
Winteler HV, Haas D
Microbiology (Reading) 1996 Mar;142 ( Pt 3):685-693
PubMed ID: 8868444