Pseudomonas aeruginosa PAO1, PA1633 (kdpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1633
Name
kdpA
Replicon chromosome
Genomic location 1776045 - 1777739 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250324.1
GI 15596830
Affymetrix PA1633_kdpA_at
Entrez 883055
GenBank AAG05022.1
INSDC AAG05022.1
NCBI Locus Tag PA1633
protein_id(GenBank) gb|AAG05022.1|AE004591_2|gnl|PseudoCAP|PA1633
TIGR NTL03PA01634
UniParc UPI000012625F
UniProtKB Acc P57683
UniProtKB ID ATKA_PSEAE
UniRef100 UniRef100_P57683
UniRef50 UniRef50_P57683
UniRef90 UniRef90_P57683

Product

Feature Type CDS
Coding Frame 1
Product Name
potassium-transporting ATPase, A chain
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 2.97
Kyte-Doolittle Hydrophobicity Value 0.669
Molecular Weight (kDa) 59.9
Isoelectric Point (pI) 7.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Membrane Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 253 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003741 (509 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1633
Search term: kdpA

Human Homologs

References

Sequence homology between two membrane transport ATPases, the Kdp-ATPase of Escherichia coli and the Ca2+-ATPase of sarcoplasmic reticulum.
Hesse JE, Wieczorek L, Altendorf K, Reicin AS, Dorus E, Epstein W
Proc Natl Acad Sci U S A 1984 Aug;81(15):4746-50
PubMed ID: 6146979
The K+-translocating Kdp-ATPase from Escherichia coli. Purification, enzymatic properties and production of complex- and subunit-specific antisera.
Siebers A, Altendorf K
Eur J Biochem 1988 Dec 1;178(1):131-40
PubMed ID: 2849541
Assembly of the Kdp complex, the multi-subunit K+-transport ATPase of Escherichia coli.
Gassel M, Siebers A, Epstein W, Altendorf K
Biochim Biophys Acta 1998 Dec 9;1415(1):77-84
PubMed ID: 9858692